EFFECT OF CHITOSAN ON THE RHEOLOGICAL PROPERTIES OF HYDROGELS BASED ON SODIUM CARBOXYMETHYLCELLULOSE

被引：3
|
作者：
Szczesniak, Maria [1 ]
Grimling, Bozena [1 ]
Pinta, Janusz [1 ]
Meler, Jan [1 ]
机构：
[1] Wroclaw Med Univ, Fac Pharm, Ul Borowska 211 A, PL-50556 Wroclaw, Poland
来源：
PROGRESS ON CHEMISTRY AND APPLICATION OF CHITIN AND ITS DERIVATIVES | 2015年 / 20卷
关键词：
chitosan; sodium carboxymethylcellulose; pharmaceutical availability; rheological parameters;
D O I：
10.15259/PCACD.20.25
中图分类号：
TB3 [工程材料学]; R318.08 [生物材料学];
学科分类号：
0805 ; 080501 ; 080502 ;
摘要：
The aim of the study was to evaluate the effect of changing the concentrations of chitosan on the rheological properties of the obtained formulation. Hydrogels were prepared with 1% hydrocortisone containing 4% sodium carboxymethylcellulose with the addition of chitosan, propylene glycol-1,2 or polyethylene glycol 400 and glycerol or paraffin. The concentration of chitosan and excipients affects the rheological properties of gels and the pharmaceutical availability of hydrocortisone. Increasing the concentration of chitosan have influence on increasing the viscosity, hardness, and cohesiveness of the tested gels.
引用
收藏
页码：254 / 259
页数：6
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