NEW ENANTIOSELECTIVE APPROACH TO ALPHA-ALLOKAINOIDS BY MICHAEL ADDITION TO CHIRAL 4-SUBSTITUTED 2,3-DIDEHYDROPROLINATE

被引:25
作者
EZQUERRA, J
ESCRIBANO, A
RUBIO, A
REMUINAN, MJ
VAQUERO, JJ
机构
[1] CTR INVEST LILLY, E-28130 MADRID, SPAIN
[2] UNIV ALCALA DE HENARES, DEPT QUIM ORGAN, E-28871 ALCALA DE HENARES, SPAIN
关键词
D O I
10.1016/0040-4039(95)01165-E
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
(-) and (+) alpha-Allokainoids hydrochlorides 3 and 4 were obtained by hydrolysis of the corresponding Michael adducts resulting from the addition of diethyl malonate to chiral N-urethane protected ethyl 4-benzyl-2,3-didehydroprolinates 9 and 13 respectively.
引用
收藏
页码:6149 / 6152
页数:4
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