STABILIZATION OF THYMOPENTIN AND PRESERVATION OF ITS PHARMACOLOGICAL PROPERTIES BY 2-HYDROXYPROPYL-BETA-CYCLODEXTRIN

被引：6

作者：

BROWN, ND

BUTLER, DL

CHIANG, PK

机构：

[1] Department of Applied Biochemistry, Walter Reed Army Institute of Research, Washington, District of Columbia

来源：

JOURNAL OF PHARMACY AND PHARMACOLOGY | 1993年 / 45卷 / 07期

关键词：

D O I：

10.1111/j.2042-7158.1993.tb05675.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Thymopentin prepared in 5, 15, and 20% 2-hydroxypropyl-beta-cyclodextrin (HPCD) was able to inhibit guinea-pig ileum contraction stimulated by anatoxin-a (3 x 10(-6) M) after fourteen months of storage at room temperature. Thus, in contrast to the instability of thymopentin prepared without HPCD, the pharmacological activity was retained and could be stored in a ready-to-use solution for extended periods without refrigeration.

引用

收藏

页码：666 / 667

页数：2

相关论文

共 13 条

[1] ANATOXIN-A INTERACTIONS WITH CHOLINERGIC SYNAPTIC MOLECULES [J].

ARONSTAM, RS ;

WITKOP, B .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1981, 78 (07) :4639-4643

[2] USE OF 2-HYDROXYPROPYL-BETA-CYCLODEXTRIN AS A SOLUBILIZING AND STABILIZING EXCIPIENT FOR PROTEIN DRUGS [J].

BREWSTER, ME ;

HORA, MS ;

SIMPKINS, JW ;

BODOR, N .

PHARMACEUTICAL RESEARCH, 1991, 8 (06) :792-795

[3] TOXICOLOGY AND PHARMACOLOGICAL ACTION OF ANABAENA FLOS-AQUAE TOXIN [J].

CARMICHAEL, WW ;

BIGGS, DF ;

GORHAM, PR .

SCIENCE, 1975, 187 (4176) :542-544

[4] NICOTINIC ACTION OF ANATOXIN-A ON GUINEA-PIG ILEUM ANTAGONIZED BY THYMOPENTIN [J].

CHIANG, PK ;

BUTLER, DL ;

BROWN, ND .

LIFE SCIENCES, 1991, 49 (06) :PL13-PL19

[5] ANATOXIN-A, A TOXIC ALKALOID FROM ANABAENA-FLOS-AQUAE NRC-44H [J].

DEVLIN, JP ;

EDWARDS, OE ;

GORHAM, PR ;

HUNTER, NR ;

PIKE, RK ;

STAVRIC, B .

CANADIAN JOURNAL OF CHEMISTRY-REVUE CANADIENNE DE CHIMIE, 1977, 55 (08) :1367-1371

[6]

GORDON RK, 1989, MOL PHARMACOL, V36, P766

[7]

OCHOA ELM, 1990, MOL PHARMACOL, V38, P863

[8]

SEPTOV NF, 1991, PEPTIDE RES, V4, P308

[9] CARDIOVASCULAR EFFECTS OF ANATOXIN-A IN THE CONSCIOUS RAT [J].

SIREN, AL ;

FEUERSTEIN, G .

TOXICOLOGY AND APPLIED PHARMACOLOGY, 1990, 102 (01) :91-100

[10]

SPIVAK CE, 1980, MOL PHARMACOL, V18, P384