Pedigree Study of Familial Alzheimer Disease

被引：25
作者：
Powell, Diane [1 ]
Folstein, Marshal F. [1 ]
机构：
[1] Johns Hopkins Univ, Sch Med, Dept Psychiat, Baltimore, MD 21205 USA
来源：
JOURNAL OF NEUROGENETICS | 1984年 / 1卷 / 02期
关键词：
Alzheimer disease; pedigree study;
D O I：
10.3109/01677068409107085
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Twenty-one families with familial Alzheimer disease were ascertained in a dementia clinic and assessed by multiple family interviews. Eight autopsies were reviewed. The age of onset varied from 25 to 85. Seven pedigrees showed evidence of 3 generation transmission. Paternal age of the founders of 4 lines which could be assessed was higher than controls.
引用
收藏
页码：189 / 197
页数：9
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