TRICYCLIC INHIBITORS OF GASTRIC-ACID SECRETION .3. CARBAZOLES

被引：0
|
作者：
CANASRODRIGUEZ, A
MATEOBERNARDO, A
机构：
来源：
ANALES DE QUIMICA SERIE C-QUIMICA ORGANICA Y BIOQUIMICA | 1987年 / 83卷 / 01期
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中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
In contrast to the 3-tert-butyl substituted phenothiazines and 1,2,3,4-tetrahydrocarbazoles already studied by us, the carbazole analogues lack gastric acid inhibitory properties in spite of similar Log P values. A possible explanation for this study could be that the coplanarity of the heterocyclic system with the nuclear substituents prevents these compounds from achieving a good fit with the appropriate receptor.
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页码：18 / 20
页数：3
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