RAPID EXCLUSION OF CHROMOSOMAL ANEUPLOIDIES BY FLUORESCENCE IN-SITU HYBRIDIZATION PRIOR TO FETAL SURGERY FOR OBSTRUCTIVE UROPATHY - A CASE-REPORT

被引：6

作者：

SKUPSKI, DW ^{[1
]}

EDDLEMAN, KA ^{[1
]}

ZELLERS, N ^{[1
]}

WARD, BE ^{[1
]}

机构：

[1] CORNELL UNIV,MED CTR,DIV MATERNAL FETAL MED,NEW YORK,NY 10021

来源：

FETAL DIAGNOSIS AND THERAPY | 1994年 / 9卷 / 05期

关键词：

OBSTRUCTIVE UROPATHY; FLUORESCENCE IN SITU HYBRIDIZATION; PRENATAL DIAGNOSIS; FETAL SURGERY; CONGENITAL GENITOURINARY ANOMALY; VESICOAMNIOTIC SHUNT;

D O I：

10.1159/000263961

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Ultrasound of a fetus at 17 weeks gestation revealed posterior urethral valve syndrome with anhydramnios. Fluorescence in situ hybridization (FISH) to detect aneuploidies of chromosomes 13, 18, 21, X and Y was performed on transitional cells from the fetal bladder obtained at percutaneous vesicocentesis, followed by conventional cytogenetics. Fetal urine was chosen due to unavailability of amniotic fluid for karyotypic analysis. A nonlethal (disomic) karyotype was suggested by FISH, and thus placement of a vesicoamniotic shunt was performed. The ability to prognosticate in cases of obstructive uropathy is not absolute, and fetal surgery for relief of urinary obstruction is best performed at the earliest possible gestational age. Thus, all available means for rapidly ruling out lethal congenital anomalies should be undertaken in cases of obstructive uropathy prior to any decision regarding fetal surgery.

引用

页码：353 / 356

页数：4

共 12 条

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