Short interfering RNA in cancer therapy

被引：0
作者：
Majorek, Maria [1 ]
Guzenda, Piotr [1 ]
Lamparska-Przybysz, Monika [1 ]
Wieczorek, Maciej [1 ]
机构：
[1] Dzial Badawczo Rozwojowy Celon Pharma Sp, Lab Biol Molekularnej, Wroclaw, Poland
来源：
WSPOLCZESNA ONKOLOGIA-CONTEMPORARY ONCOLOGY | 2006年 / 10卷 / 08期
关键词：
anticancer therapy; gene silencing; RNA interference (RNAi); small interfering RNA (siRNA);
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Despite modern application of surgical treatment as well as radio- and chemotherapy the results of cancer treatment are still disappointing. Genetic engineering brings new hopes and capability of interference in the genome of tumour cells for regulation of function of genes responsible for transformation and progression of cancer. Discovery of the phenomenon of interference RNA has initiated research by using small interfering RNA (siRNA) for gene silencing in mammalian cells. Natural occurrence of this phenomenon in eukaryotic organisms provides the greatest efficiency and specificity in comparison with other methods of gene silencing such as antisense oligonucleotides and ribozymes. Despite the existence of technical challenges related to specificity, synthesis and feeding siRNA, this molecule has great therapeutic capabilities in treatment of such complicated sickness as advanced tumours.
引用
收藏
页码：367 / 372
页数：6
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