Common Carotid Arteries Occlusion Surgery in Adult Rats as a Model of Chronic Cerebral Hypoperfusion

被引：15
作者：
Cao, Dandan [1 ]
Bai, Yunfei [1 ]
Li, Liang [1 ]
机构：
[1] CapitalMed Univ, Dept Pathol, Sch BasicMed Sci, 10 Xi Tou Tiao,You An Men St, Beijing, Peoples R China
来源：
BIO-PROTOCOL | 2018年 / 8卷 / 02期
基金：
中国国家自然科学基金;
关键词：
Chronic cerebral hypoperfusion; Vascular dementia; Alzheimer's disease; Two-vessel occlusion; Cerebral blood flow; White matter;
D O I：
10.21769/BioProtoc.2704
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Chronic cerebral hypoperfusion (CCH) is an important risk factor of vascular dementia (VaD) and Alzheimer's disease (AD). Hypoxia/ischemia in the whole brain induced by CCH causes serious damage to brain structure and function, which can lead to cognitive impairment. Two-vessel occlusion (2-VO), also known as permanent, bilateral common carotid artery occlusion, is one of the most widely used animal models (e.g., rat) of CCH to investigate the mechanisms of neurodegenerative processes. In this protocol, we present the surgical procedure for 2-VO in rats.
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页数：10
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共 23 条
[1]   The chronic vascular and haemodynamic response after permanent bilateral common carotid occlusion in newborn and adult rats [J].
Choy, ManKin ;
Ganesan, Vijeya ;
Thomas, David L. ;
Thornton, John S. ;
Proctor, Edward ;
King, Martin D. ;
van der Weerd, Louise ;
Gadian, David G. ;
Lythgoe, Mark F. .
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 2006, 26 (08) :1066-1075
[2]   Inhibitory avoidance memory retention in the elevated T-maze is impaired after perivascular manipulation of the common carotid arteries [J].
de Bortoli, VC ;
Zangrossi, H ;
Corrêa, FMD ;
Almeida, SD ;
de Oliveira, AM .
LIFE SCIENCES, 2005, 76 (18) :2103-2114
[3]  
De La Torre JC, 2002, ANN NY ACAD SCI, V977, P196
[4]   Life and death of nerve cells: Therapeutic cytokine signaling pathways [J].
Eisel, Ulrich L. M. ;
Biber, Knut ;
Luiten, Paul G. M. .
CURRENT SIGNAL TRANSDUCTION THERAPY, 2006, 1 (02) :133-146
[5]   Diazoxide and dimethyl sulphoxide prevent cerebral hypoperfusion-related learning dysfunction and brain damage after carotid artery occlusion [J].
Farkas, E ;
Institóris, A ;
Domoki, F ;
Mihály, A ;
Luiten, PGM ;
Bari, F .
BRAIN RESEARCH, 2004, 1008 (02) :252-260
[6]   Experimental cerebral hypoperfusion induces white matter injury and microglial activation in the rat brain [J].
Farkas, E ;
Donka, G ;
de Vos, RAI ;
Mihály, A ;
Bari, F ;
Luiten, PGM .
ACTA NEUROPATHOLOGICA, 2004, 108 (01) :57-64
[7]   Cerebral microvascular pathology in aging and Alzheimer's disease [J].
Farkas, E ;
Luiten, PGM .
PROGRESS IN NEUROBIOLOGY, 2001, 64 (06) :575-611
[8]   Permanent, bilateral common carotid artery occlusion in the rat: A model for chronic cerebral hypoperfusion-related neurodegenerative diseases [J].
Farkas, Eszter ;
Luiten, Paul G. M. ;
Bari, Ferenc .
BRAIN RESEARCH REVIEWS, 2007, 54 (01) :162-180
[9]   A Novel Mouse Model of Subcortical Infarcts with Dementia [J].
Hattori, Yorito ;
Enmi, Jun-ichiro ;
Kitamura, Akihiro ;
Yamamoto, Yumi ;
Saito, Satoshi ;
Takahashi, Yukako ;
Iguchi, Satoshi ;
Tsuji, Masahiro ;
Yamahara, Kenichi ;
Nagatsuka, Kazuyuki ;
Iida, Hidehiro ;
Ihara, Masafumi .
JOURNAL OF NEUROSCIENCE, 2015, 35 (09) :3915-3928
[10]   Chronic cerebral hypoperfusion accelerates amyloid β deposition in APPSwInd transgenic mice [J].
Kitaguchi, Hiroshi ;
Tomimoto, Hidekazu ;
Ihara, Masafumi ;
Shibata, Masunari ;
Uemura, Kengo ;
Kalaria, Rajesch N. ;
Kihara, Takeshi ;
Asada-Utsugi, Megumi ;
Kinoshita, Ayae ;
Takahashi, Ryosuke .
BRAIN RESEARCH, 2009, 1294 :202-210
123