SYNTHESIS AND CHARACTERIZATION OF A SERIES OF HYDROPHOBIC ANTITUMOR BIS(CARBOXYLATO) (1,2-DIAMINOCYCLOHEXANE) PLATINUM(II) COMPLEXES

被引：15
作者：
ALBAKER, S [1 ]
PEREZSOLER, R [1 ]
KHOKHAR, AR [1 ]
机构：
[1] UNIV TEXAS,MD ANDERSON CANC CTR,DEPT MED ONCOL,BOX 52,1515 HOLCOMBE BLVD,HOUSTON,TX 77030
来源：
JOURNAL OF COORDINATION CHEMISTRY | 1993年 / 29卷 / 1-2期
关键词：
PLATINUM; 1,2-DIAMINOCYCLOHEXANE; CARBOXYLATE; LIPOSOMES; HYDROPHOBIC; SYNTHESIS;
D O I：
10.1080/00958979308037119
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
A series of hydrophobic platinum(II) complexes of the type (DACH)PtX2 (where DACH = various isomeric forms of 1,2-diaminocyclohexane and X=pentanoato, hexanoato, heptanoato, octanoato, nonanoato, decanoato, unidecanoato, laurato, tridecanoato, myristato, pentadecanoato, palmitato, heptadecanoato, or stearato) has been synthesized and characterized using elemental analysis, infrared spectra and nuclear magnetic resonance (C-13{H-1} and Pt-195{H-1}). The complexes have been prepared as potential antitumor agents for liposome entrapment.
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页码：1 / 6
页数：6
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