Neurophysiological dysfunctions and alterations in the quality of life in populations with amyotrophic lateral sclerosis

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that gradually deteriorates motor neurons. The cerebral cortex is one of the most affected areas during the course of ALS committing regions of the brainstem and basal ganglia. The damage caused by this disease occurs on a neuromotor and respiratory level; being this the last cause of deaths in patients who have it. The Quality of Life (QoL) in populations with this disease tends to decrease significantly, and the methods of diagnosis and forecasting are ineffective when detecting ALS and address it effectively. More interdisciplinary studies need to be done in order to improve the degree of QoL in patients that have ALS and their caregivers.