ANTI-IL-10 TREATMENT DOES NOT BLOCK EITHER THE INDUCTION OR THE MAINTENANCE OF ORALLY INDUCED TOLERANCE TO OVA

被引：37

作者：

AROEIRA, LS

CARDILLO, F

DEALBUQUERQUE, DA

VAZ, NM

MENGEL, J

机构：

[1] UNIV CAMPINAS,INST BIOL,DEPT IMMUNOL & MICROBIOL,BR-13081970 SAO PAULO,BRAZIL

[2] UNIV FED MINAS GERAIS,INST BIOL SCI,DEPT BIOCHEM & IMMUNOL,BELO HORIZONT,MG,BRAZIL

[3] UNIV SAO PAULO,FAC MED RIBEIRAO PRETO,DEPT IMMUNOL,BR-05508 SAO PAULO,BRAZIL

来源：

SCANDINAVIAN JOURNAL OF IMMUNOLOGY | 1995年 / 41卷 / 04期

关键词：

D O I：

10.1111/j.1365-3083.1995.tb03573.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Herein, the role of IL-10 in the induction and maintenance of oral tolerance was evaluated. The results show that: (1) mice treated with MoAb anti-IL-10 are permissive to the induction of oral tolerance to OVA; (2) anti-IL-10 treatment did not reverse the in vitro blocking of T cell proliferative response found in orally-tolerized mice; and (3) orally-induced tolerance could not be broken by anti-IL-10 treatment. Taken together, these results suggest that IL-10 is not a fundamental cytokine for the establishment and maintenance of oral tolerance.

引用

页码：319 / 323

页数：5

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