DIETARY MODULATION OF ALCOHOL-INDUCED PANCREATIC INJURY

被引：19

作者：

HORNE, WI ^{[1
]}

TSUKAMOTO, H ^{[1
]}

机构：

[1] METROHLTH MED CTR,DEPT MED,DIV GASTROENTEROL,CLEVELAND,OH 44109

来源：

ALCOHOL | 1993年 / 10卷 / 06期

关键词：

ALCOHOL-INDUCED PANCREATIC DISEASE; PANCREAS; ALCOHOL; APOPTOSIS; ACINAR ATROPHY; DIET EFFECT ON ALCOHOL-INDUCED PANCREATIC DISEASE;

D O I：

10.1016/0741-8329(93)90069-Z

中图分类号：

R194 [卫生标准、卫生检查、医药管理];

学科分类号：

摘要：

This is a review of current progress in studies of alcohol-induced pancreatic injury using the rat intragastric ethanol infusion model. This model has been shown to reproduce the histopathologic characteristics of human ethanol-related pancreatic disease in a rodent model. A high fat liquid diet infused with ethanol potentiated the histologic and cellular effects of ethanol on the exocrine pancreas when compared to a low fat diet-ethanol infusion. Hypogranulation and apoptosis of pancreatic acinar cells are proposed as precursor lesions induced by ethanol leading to the subsequent development of acinar atrophy. A reduction in acinar cell sensitivity and responsiveness to cholecystokinin (CCK) is documented and proposed as a mechanism for the development of regressive changes through a reduction in the trophic effect of CCK.

引用

页码：481 / 484

页数：4

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