DIETARY MODULATION OF ALCOHOL-INDUCED PANCREATIC INJURY

被引：19

作者：

HORNE, WI ^{[1
]}

TSUKAMOTO, H ^{[1
]}

机构：

[1] METROHLTH MED CTR,DEPT MED,DIV GASTROENTEROL,CLEVELAND,OH 44109

来源：

ALCOHOL | 1993年 / 10卷 / 06期

关键词：

ALCOHOL-INDUCED PANCREATIC DISEASE; PANCREAS; ALCOHOL; APOPTOSIS; ACINAR ATROPHY; DIET EFFECT ON ALCOHOL-INDUCED PANCREATIC DISEASE;

D O I：

10.1016/0741-8329(93)90069-Z

中图分类号：

R194 [卫生标准、卫生检查、医药管理];

学科分类号：

摘要：

This is a review of current progress in studies of alcohol-induced pancreatic injury using the rat intragastric ethanol infusion model. This model has been shown to reproduce the histopathologic characteristics of human ethanol-related pancreatic disease in a rodent model. A high fat liquid diet infused with ethanol potentiated the histologic and cellular effects of ethanol on the exocrine pancreas when compared to a low fat diet-ethanol infusion. Hypogranulation and apoptosis of pancreatic acinar cells are proposed as precursor lesions induced by ethanol leading to the subsequent development of acinar atrophy. A reduction in acinar cell sensitivity and responsiveness to cholecystokinin (CCK) is documented and proposed as a mechanism for the development of regressive changes through a reduction in the trophic effect of CCK.

引用

页码：481 / 484

页数：4

共 20 条

[1] PATHO-PHYSIOLOGY OF ACUTE AND CHRONIC-PANCREATITIS [J].

BALART, LA ;

FERRANTE, WA .

ARCHIVES OF INTERNAL MEDICINE, 1982, 142 (01) :113-117

[2]

DARLE N, 1970, GASTROENTEROLOGY, V58, P62

[3] MULTICENTER SURVEY OF THE ETIOLOGY OF PANCREATIC DISEASES - RELATIONSHIP BETWEEN THE RELATIVE RISK OF DEVELOPING CHRONIC-PANCREATITIS AND ALCOHOL, PROTEIN AND LIPID CONSUMPTION [J].

DURBEC, JP ;

SARLES, H .

DIGESTION, 1978, 18 (5-6) :337-350

[4]

GREENBERGER J, 1991, HARRISONS PRINCIPLES, V2, P1372

[5] OBSERVATIONS ON 205 CONFIRMED CASES OF ACUTE PANCREATITIS RECURRING PANCREATITIS AND CHRONIC PANCREATITIS [J].

SARLES, H ;

SARLES, JC ;

CAMATTE, R ;

MURATORE, R ;

GAINI, M ;

GUIEN, C ;

PASTOR, J ;

LEROY, F .

GUT, 1965, 6 (06) :545-&

[6] COMPARISON OF ALCOHOLIC PANCREATITIS IN RAT AND MAN [J].

SARLES, H ;

LEBREUIL, G ;

TASSO, F ;

FIGARELLA, C ;

CLEMENTE, F ;

DEVAUX, MA ;

FAGONDE, B ;

PAYAN, H .

GUT, 1971, 12 (05) :377-+

[7] CHRONIC CALCIFYING PANCREATITIS - CHRONIC-ALCOHOLIC PANCREATITIS [J].

SARLES, H .

GASTROENTEROLOGY, 1974, 66 (04) :604-616

[8]

SINGH M, 1982, GASTROENTEROLOGY, V82, P425

[9] SEVERE AND PROGRESSIVE STEATOSIS AND FOCAL NECROSIS IN RAT-LIVER INDUCED BY CONTINUOUS INTRAGASTRIC INFUSION OF ETHANOL AND LOW FAT DIET [J].

TSUKAMOTO, H ;

FRENCH, SW ;

BENSON, N ;

DELGADO, G ;

RAO, GA ;

LARKIN, EC ;

LARGMAN, C .

HEPATOLOGY, 1985, 5 (02) :224-232

[10]

TSUKAMOTO H, 1988, AM J PATHOL, V131, P246

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