CLINICAL-EVALUATION OF THE EFFECT OF OMEPRAZOLE, CIMETIDINE, FAMOTIDINE AND RANITIDINE ON HISTAMINE-INDUCED CUTANEOUS WHEAL AND FLARE RESPONSE

被引：0
|
作者：
SAHA, N
SACHDEV, A
BHASIN, DK
SANKARANAHYANAN, A
KHOSLA, PP
SINGH, K
SHARMA, PL
机构：
[1] PGIMER,IND,DEPT PHARMACOL,CHANDIGARH 160012,INDIA
[2] PGIMER DEPT GASTROENTEROL,CHANDIGARH,INDIA
来源：
INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS | 1993年 / 31卷 / 07期
关键词：
HISTAMINE; CIMETIDINE; FAMOTIDINE; OMEPRAZOLE; RANITIDINE; SKIN TESTING; WHEAL AND FLARE;
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The effect of H-2 receptor antagonists on immediate cutaneous response to allergens remain controversial. In the present study, the effect of 7-day administration of omeprazole, cimetidine, famotidine and ranitidine on histamine induced wheal and flare reaction was evaluated. A single blind randomized parallel group study with within patient comparison of responses was planned in non-ulcer dyspepsia patients eligible to receive H-2 antagonists or omeprazole. None of the drugs produced any changes in the area of the wheal in comparison to respective baseline values. The area of flare was decreased by all the drugs and the percentage decrease in this parameter caused by omprazole, cimetidine, famotidine and ranitidine was 2.4, 12.3, 20.2 and 13.2, respectively. Only famotidine caused a significant decrease in flare area (p < 0.05).
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页码：322 / 325
页数：4
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