INFLUENCE OF THE STERILIZATION PROCESS ON ALGINATE DISPERSIONS

被引：19

作者：

VANDENBOSSCHE, GMR ^{[1
]}

REMON, JP ^{[1
]}

机构：

[1] STATE UNIV GHENT,PHARMACEUT TECHNOL LAB,HARELBEKESTR 72,B-9000 GHENT,BELGIUM

来源：

JOURNAL OF PHARMACY AND PHARMACOLOGY | 1993年 / 45卷 / 05期

关键词：

D O I：

10.1111/j.2042-7158.1993.tb05582.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The influence of different sterilization procedures on alginate dispersions was studied by measuring viscosity and molecular weight changes. Autoclaving caused a 64% decrease in viscosity. Heating at a low temperature over several cycles was less efficient in sterilizing alginates and there was a progressive breakdown of the alginate chain over the succeeding cycles. Heating during ethylene oxide sterilization also resulted in reduced viscosity and breakdown. Membrane filtration yielded a sterile product with no significant reduction in viscosity or mol. wt.

引用

页码：484 / 486

页数：3

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