Results of a systematic study of the degradation behaviour of nMOSTs stressed at 4.2 K will be reported. It will be shown that the stress-induced changes can be classified in reversible and irreversible (permanent) degradation, which strongly depend on the operation conditions during stress. The reversible changes are mainly related to hole-trapping in the body of the transistor and are accompanied by a decrease of the threshold voltage and a small transconductance overshoot. The effect of Channel Hot Carrier (CHC) stress on the typical 4.2 K anomalies (kink/hysteresis) will also be addressed and briefly discussed in view of recently published models.