Endocrinology of bone/brain crosstalk

被引：2

作者：

Metozzi, Alessia ^{[1
]}

Bonamassa, Lorenzo ^{[1
]}

Brandi, Gemma ^{[2
]}

Brandi, Maria Luisa ^{[3
]}

机构：

[1] Univ Florence, Dept Surg & Translat Med, Metab Bone Dis Unit, I-50138 Florence, Italy

[2] Publ Mental Hlth Syst 1 4 Florence, Florence, Italy

[3] Univ Florence, AOUC Careggi, Dept Surg & Translat Med, Metab Bone Dis Unit, Largo Palagi 1, Florence, Italy

来源：

EXPERT REVIEW OF ENDOCRINOLOGY & METABOLISM | 2015年 / 10卷 / 02期

关键词：

5-OH-tryptamine; adrenocorticotropin; animal and human studies; beta-adrenergic system; bone remodeling; brain-derived neurotrophic factor; cannabinoids; CNS; depression; leptin; neuropeptides; osteoporosis disease; sympathetic nervous system;

D O I：

10.1586/17446651.2015.979787

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Bone metabolism is regulated by the action of two skeletal cells: osteoblasts and osteoclasts. This process is controlled by many genetic, hormonal and lifestyle factors, but today more and more studies have allowed us to identify a neuronal regulation system termed 'bone-brain crosstalk', which highlights a direct relationship between bone tissue and the nervous system. The first documentation of an anatomic relationship between nerves and bone was made via a wood cut by Charles Estienne in Paris in 1545. His diagram demonstrated nerves entering and leaving the bones of a skeleton. Later, several studies were conducted on bone innervation and, as of today, many observations on the regulation of bone remodeling by neurons and neuropeptides that reside in the CNS have created a new research field, that is, neuroskeletal research.

引用

页码：153 / 167

页数：15

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