SYNTHESIS AND PRELIMINARY PHARMACOLOGICAL STUDY OF THIOPHENE ANALOGS OF THE ANTIPYRETIC AND ANALGESIC AGENT ETHENZAMIDE

被引：20

作者：

DARIAS, V ^{[1
]}

BRAVO, L ^{[1
]}

ABDALLAH, SS ^{[1
]}

MATEO, CCS ^{[1
]}

EXPOSITOORTA, MA ^{[1
]}

LISSAVETSKY, J ^{[1
]}

MANZANARES, J ^{[1
]}

机构：

[1] CSIC,INST QUIM MED,E-28006 MADRID,SPAIN

来源：

ARCHIV DER PHARMAZIE | 1992年 / 325卷 / 02期

关键词：

D O I：

10.1002/ardp.19923250206

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A preliminary pharmacological study of a thiophene analogue 1b of the analgesic and antipyretic agent Ethenzamide and of a closely related compound 1a showed that a great similarity exists among Ethenzamide and the thiophenic compounds for analgesic, antipyretic, ulcerogenic, hypothermic, and sedative effects. However, the acute toxicity in mice for the thiophenic compounds is notably higher than that of Ethenzamide.

引用

页码：83 / 87

页数：5

共 21 条

[1] SOME ASPECTS OF PHARMACOLOGY OF IBUFENAC A NON-STEROIDAL ANTI-INFLAMMATORY AGENT [J].