ISOLATION OF 2 DISTINCT TYPE-I ANGIOTENSIN-II RECEPTOR GENES

被引：132

作者：

ELTON, TS

STEPHAN, CC

TAYLOR, GR

KIMBALL, MG

MARTIN, MM

DURAND, JN

OPARIL, S

机构：

[1] Vascular Biology and Hypertension Program Division, Cardiovascular Disease Department, Medicine University of Alabama at Birmingham, Birmingham

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1992年 / 184卷 / 02期

关键词：

D O I：

10.1016/0006-291X(92)90700-U

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A rat genomic Southern blot, probed with a type I angiotensin II receptor probe, demonstrated that two highly homologous type I angiotensin II receptors were present. A rat genomic library was subsequently screened and four clones were isolated. From restriction mapping, differential hybridization, polymerase chain reaction amplification and sequence analyses we have determined that there are two unique type I angiotensin II receptor genes. The first of these genes corresponds to the published rat vascular complementary DNA sequence; the second, corresponds to a novel receptor not previously described. © 1992.

引用

页码：1067 / 1073

页数：7

共 15 条

[1] A COMPREHENSIVE SET OF SEQUENCE-ANALYSIS PROGRAMS FOR THE VAX [J].

DEVEREUX, J ;

HAEBERLI, P ;

SMITHIES, O .

NUCLEIC ACIDS RESEARCH, 1984, 12 (01) :387-395

[2] CLONING OF THE GENE AND CDNA FOR MAMMALIAN BETA-ADRENERGIC-RECEPTOR AND HOMOLOGY WITH RHODOPSIN [J].

DIXON, RAF ;

KOBILKA, BK ;

STRADER, DJ ;

BENOVIC, JL ;

DOHLMAN, HG ;

FRIELLE, T ;

BOLANOWSKI, MA ;

BENNETT, CD ;

RANDS, E ;

DIEHL, RE ;

MUMFORD, RA ;

SLATER, EE ;

SIGAL, IS ;

CARON, MG ;

LEFKOWITZ, RJ ;

STRADER, CD .

NATURE, 1986, 321 (6065) :75-79

[3] STRUCTURE OF THE GENE FOR HUMAN BETA-2-ADRENERGIC RECEPTOR - EXPRESSION AND PROMOTER CHARACTERIZATION [J].

EMORINE, LJ ;

MARULLO, S ;

DELAVIERKLUTCHKO, C ;

KAVERI, SV ;

DURIEUTRAUTMANN, O ;

STROSBERG, AD .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (20) :6995-6999

[4]

FEINBERG AP, 1981, ANAL BIOCHEM, V132, P6

[5] TURNING OFF THE SIGNAL - DESENSITIZATION OF BETA-ADRENERGIC-RECEPTOR FUNCTION [J].

HAUSDORFF, WP ;

CARON, MG ;

LEFKOWITZ, RJ .

FASEB JOURNAL, 1990, 4 (11) :2881-2889

[6] RAT ANGIOTENSIN-II RECEPTOR - CDNA SEQUENCE AND REGULATION OF THE GENE-EXPRESSION [J].

IWAI, N ;

YAMANO, Y ;

CHAKI, S ;

KONISHI, F ;

BARDHAN, S ;

TIBBETTS, C ;

SASAKI, K ;

HASEGAWA, M ;

MATSUDA, Y ;

INAGAMI, T .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1991, 177 (01) :299-304

[7]

KOBILKA BK, 1987, J BIOL CHEM, V262, P7321

[8] AN INTRONLESS GENE ENCODING A POTENTIAL MEMBER OF THE FAMILY OF RECEPTORS COUPLED TO GUANINE-NUCLEOTIDE REGULATORY PROTEINS [J].

KOBILKA, BK ;

FRIELLE, T ;

COLLINS, S ;

YANGFENG, T ;

KOBILKA, TS ;

FRANCKE, U ;

LEFKOWITZ, RJ ;

CARON, MG .

NATURE, 1987, 329 (6134) :75-79

[9] CLONING, SEQUENCING, AND EXPRESSION OF THE GENE CODING FOR THE HUMAN-PLATELET ALPHA-2-ADRENERGIC RECEPTOR [J].

KOBILKA, BK ;

MATSUI, H ;

KOBILKA, TS ;

YANGFENG, TL ;

FRANCKE, U ;

CARON, MG ;

LEFKOWITZ, RJ ;

REGAN, JW .

SCIENCE, 1987, 238 (4827) :650-656

[10] ISOLATION OF A CDNA-ENCODING THE VASCULAR TYPE-1 ANGIOTENSIN-II RECEPTOR [J].

MURPHY, TJ ;

ALEXANDER, RW ;

GRIENDLING, KK ;

RUNGE, MS ;

BERNSTEIN, KE .

NATURE, 1991, 351 (6323) :233-236

← 1 2 →