A NEW GENERATION OF CALCIUM-ANTAGONISTS AND THEIR ROLE IN ATHEROSCLEROSIS

被引：16
作者：
PAOLETTI, R
BERNINI, F
机构：
[1] Institute of Pharmacological Sciences, University of Milan, Milan
来源：
AMERICAN JOURNAL OF CARDIOLOGY | 1990年 / 66卷 / 18期
关键词：
D O I：
10.1016/0002-9149(90)90573-J
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
A new generation of calcium antagonists is being developed in an attempt to improve the already widespread therapeutic applications of this class of drugs. In this report the effect of these new calcium antagonists on those processes involved in atherogenesis that occur in the cellular component of the arterial wall is reviewed. The new generation of calcium antagonists appears to possess many of the antiatherosclerotic properties demonstrated by their prototypes. Moreover, these new compounds may have unique mechanisms of action and may be more potent than their first-generation counterparts. © 1990.
引用
收藏
页码：H28 / H31
页数：4
相关论文
共 23 条
[1]   INVITRO INHIBITION OF ARTERIAL MYOCYTE GROWTH AND STIMULATION OF LOW-DENSITY-LIPOPROTEIN METABOLISM BY SIM-6080, A NEW CALCIUM-ANTAGONISTS [J].
BERNINI, F ;
FANTONI, M ;
CORSINI, A ;
FUMAGALLI, R .
PHARMACOLOGICAL RESEARCH, 1990, 22 (01) :27-35
[2]   EFFECTS OF CALCIUM-ANTAGONISTS ON LIPIDS AND ATHEROSCLEROSIS [J].
BERNINI, F ;
CATAPANO, AL ;
CORSINI, A ;
FUMAGALLI, R ;
PAOLETTI, R .
AMERICAN JOURNAL OF CARDIOLOGY, 1989, 64 (17) :I129-I134
[3]  
BERNINI F, 1989, 1TH INT S CALC ANT
[4]  
BERTULLI SM, 1989, ATHEROSCLEROSIS CARD, V4, P819
[5]  
BETZ E, 1988, ANN NY ACAD SCI, V522, P399
[6]  
CATAPANO AL, 1988, ANN NY ACAD SCI, V522, P519
[7]   PRESERVATION OF ENDOTHELIUM-DEPENDENT VASCULAR RELAXATION IN CHOLESTEROL-FED RABBIT BY TREATMENT WITH THE CALCIUM BLOCKER PN-200110 [J].
HABIB, JB ;
BOSSALLER, C ;
WELLS, S ;
WILLIAMS, C ;
MORRISETT, JD ;
HENRY, PD .
CIRCULATION RESEARCH, 1986, 58 (02) :305-309
[8]  
HEIDER JG, 1987, TRANSPLANT P, V19, P96
[9]   MECHANISM OF ANTIATHEROGENIC ACTION OF CALCIUM-ANTAGONISTS [J].
JACKSON, CL ;
BUSH, RC ;
BOWYER, DE .
ATHEROSCLEROSIS, 1989, 80 (01) :17-26
[10]   RETARDATION OF ANGIOGRAPHIC PROGRESSION OF CORONARY-ARTERY DISEASE BY NIFEDIPINE - RESULTS OF THE INTERNATIONAL NIFEDIPINE TRIAL ON ANTIATHEROSCLEROTIC THERAPY (INTACT) [J].
LICHTLEN, PR ;
HUGENHOLTZ, PG ;
RAFFLENBEUL, W ;
HECKER, H ;
JOST, S ;
DECKERS, JW .
LANCET, 1990, 335 (8698) :1109-1113
123