VASCULAR SMOOTH-MUSCLE RELAXATION BY ENDOTHELIUM-DEPENDENT BETA-1-ADRENERGIC ACTION

被引：12

作者：

AIKAWA, J ^{[1
]}

AKATSUKA, N ^{[1
]}

机构：

[1] NATL MED CTR HOSP,DIV CARDIOL,SHINJUKU KU,TOKYO 162,JAPAN

来源：

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-PHARMACOLOGY TOXICOLOGY & ENDOCRINOLOGY | 1990年 / 97卷 / 02期

关键词：

D O I：

10.1016/0742-8413(90)90147-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

1. Norepinephrine (NE) (10(-5) M) in rabbit aorta relaxed ring segments with endothelium precontracted with 10(-6) M NE, but not segments without endothelium. 2. The relaxation was inhibited with metoprolol and methylene blue, but not inhibited with yohimbine and indomethacin. 3. NE (10(-5) M) significantly elevated tissue c-GMP levels in segments with endothelium. 4. These studies suggest that the vascular relaxation by high doses of NE is mediated by the release of endothelium-derived relaxing factor (EDRF) induced by the stimulation of beta-1-adrenoceptor.

引用

页码：311 / 315

页数：5

共 18 条

[1] ALPHA-2-ADRENOCEPTORS AND ENDOTHELIUM-DEPENDENT RELAXATION IN CANINE LARGE ARTERIES [J].

ANGUS, JA ;

COCKS, TM ;

SATOH, K .

BRITISH JOURNAL OF PHARMACOLOGY, 1986, 88 (04) :767-777

[2]

Bar H P, 1974, Adv Cyclic Nucleotide Res, V4, P195

[3]

COHEN RA, 1988, J PHARMACOL EXP THER, V244, P550

[4]

DIAMOND J, 1983, RES COMMUN CHEM PATH, V41, P369

[5]

EDWARDS JC, 1984, J PHARMACOL EXP THER, V228, P33

[6] ROLE OF ENDOTHELIUM IN RESPONSES OF VASCULAR SMOOTH-MUSCLE [J].

FURCHGOTT, RF .

CIRCULATION RESEARCH, 1983, 53 (05) :557-573

[7] THE OBLIGATORY ROLE OF ENDOTHELIAL-CELLS IN THE RELAXATION OF ARTERIAL SMOOTH-MUSCLE BY ACETYLCHOLINE [J].

FURCHGOTT, RF ;

ZAWADZKI, JV .

NATURE, 1980, 288 (5789) :373-376

[8]

HOLZMANN S, 1982, J CYCLIC NUCL PROT, V8, P409

[9] ROLE OF ENDOTHELIUM IN DILATOR RESPONSES OF SPONTANEOUSLY HYPERTENSIVE RAT ARTERIES [J].

KONISHI, M ;

SU, C .

HYPERTENSION, 1983, 5 (06) :881-886

[10] ENDOTHELIAL ALPHA-2-ADRENOCEPTORS IN CANINE PULMONARY AND SYSTEMIC BLOOD-VESSELS [J].

MILLER, VM ;

VANHOUTTE, PM .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1985, 118 (1-2) :123-129

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