SODIUM-TRANSPORT INHIBITOR FROM BOVINE HYPOTHALAMUS

被引：258

作者：

HAUPERT, GT ^{[1
]}

SANCHO, JM ^{[1
]}

机构：

[1] HARVARD UNIV,MASSACHUSETTS GEN HOSP,SCH MED,DEPT MED,MOLEC RES LAB,BOSTON,MA 02114

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1979年 / 76卷 / 09期

关键词：

D O I：

10.1073/pnas.76.9.4658

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A low molecular weight, basic, nonpeptidic factor that possesses sodium transport inhibitory properties has been prepared from bovine hypothalamus by acid/acetone extraction and gel filtration. Concentration and partial purification was achieved by ion-exchange chromatography. This substance inhibits active Na+ transport across anuran membranes, inhibits ouabain binding to frog urinary bladder, and directly inhibits renal Na+, K+-ATPase. This substance thus possesses the putative characteristics of a natriuretic factor of hypothalamic origin.

引用

页码：4658 / 4660

页数：3

共 20 条

[1] BAHLMANN J, 1967, CLIN SCI, V32, P403
[2] INHIBITION OF TRANSEPITHELIAL SODIUM TRANSPORT IN FROG SKIN BY A LOW MOLECULAR WEIGHT FRACTION OF UREMIC SERUM
BOURGOIGNIE, J
KLAHR, S
BRICKER, NS
[J]. JOURNAL OF CLINICAL INVESTIGATION, 1971, 50 (02) : 303 - +
[3] EFFECT OF DIALYSATES AND ULTRAFILTRATES OF PLASMA OF SALINE-LOADED DOGS ON TOAD BLADDER SODIUM TRANSPORT
BUCKALEW, VM
MARTINEZ, FJ
GREEN, WE
[J]. JOURNAL OF CLINICAL INVESTIGATION, 1970, 49 (05) : 926 - &
[4] ASSOCIATION OF A HUMORAL SODIUM-TRANSPORT INHIBITORY ACTIVITY WITH RENAL ESCAPE FROM CHRONIC MINERALOCORTICOID ADMINISTRATION IN DOG
BUCKALEW, VM
LANCASTER, CD
[J]. CLINICAL SCIENCE, 1972, 42 (01) : 69 - +
[5] CARRAWAY R, 1973, J BIOL CHEM, V248, P6854
[6] EFFECT OF ALDOSTERONE ON ELECTRICAL RESISTANCE OF TOAD BLADDER
CIVAN, MM
HOFFMAN, RE
[J]. AMERICAN JOURNAL OF PHYSIOLOGY, 1971, 220 (02): : 324 - &
[7] INHIBITION OF SODIUM AND POTASSIUM TRANSPORT IN SEPARATED RENAL TUBULE FRAGMENTS INCUBATED IN EXTRACTS OF URINE OBTAINED FROM SALT-LOADED INDIVIDUALS
CLARKSON, EM
DEWARDEN, HE
[J]. CLINICAL SCIENCE, 1972, 42 (05) : 607 - +
[8] EFFECT OF BRAIN EXTRACTS ON URINARY SODIUM EXCRETION OF RAT AND INTRACELLULAR SODIUM CONCENTRATION OF RENAL TUBULE FRAGMENTS
CLARKSON, EM
KOUTSAIMANIS, KG
DAVIDMAN, M
DUBOIS, M
PENN, WP
DEWARDEN.HE
[J]. CLINICAL SCIENCE AND MOLECULAR MEDICINE, 1974, 47 (03): : 201 - 213
[9] SALURETIC ACTIVITY OF BLOOD DURING CAROTID OCCLUSION IN CAT
CORT, JH
DOUSA, T
PLISKA, V
LICHARDU.B
SAFAROVA, J
VRANESIC, M
RUDINGER, J
[J]. AMERICAN JOURNAL OF PHYSIOLOGY, 1968, 215 (04): : 921 - &
[10] ENDOGENOUS DIGITALIS-LIKE ACTIVITY IN MAMMALIAN BRAIN
FISHMAN, MC
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1979, 76 (09) : 4661 - 4663

← 1 2 →