SODIUM-TRANSPORT INHIBITOR FROM BOVINE HYPOTHALAMUS

被引：258

作者：

HAUPERT, GT ^{[1
]}

SANCHO, JM ^{[1
]}

机构：

[1] HARVARD UNIV,MASSACHUSETTS GEN HOSP,SCH MED,DEPT MED,MOLEC RES LAB,BOSTON,MA 02114

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1979年 / 76卷 / 09期

关键词：

D O I：

10.1073/pnas.76.9.4658

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A low molecular weight, basic, nonpeptidic factor that possesses sodium transport inhibitory properties has been prepared from bovine hypothalamus by acid/acetone extraction and gel filtration. Concentration and partial purification was achieved by ion-exchange chromatography. This substance inhibits active Na+ transport across anuran membranes, inhibits ouabain binding to frog urinary bladder, and directly inhibits renal Na+, K+-ATPase. This substance thus possesses the putative characteristics of a natriuretic factor of hypothalamic origin.

引用

页码：4658 / 4660

页数：3

共 20 条

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