Ethosomal Curcumin Promoted Wound Healing and Reduced Bacterial Flora in Second Degree Burn in Rat

被引:31
作者
Partoazar, A. [1 ]
Kianvash, N. [2 ]
Darvishi, M. H. [3 ]
Nasoohi, S. [4 ]
Rezayat, S. M. [5 ]
Bahador, A. [6 ]
机构
[1] Univ Tehran Med Sci, Expt Med Res Ctr, Tehran, Iran
[2] Islamic Azad Univ, Pharmaceut Sci Branch, Fac Adv Sci & Technol, Dept Med Nanotechnol, Tehran, Iran
[3] Baqiyatallah Univ Med Sci, Nanobiotecnol Res Ctr, Tehran, Iran
[4] Shahid Beheshti Univ Med Sci, Fac Pharm, Dept Pharmacol & Toxicol, Tehran, Iran
[5] Univ Tehran Med Sci, Sch Med, Dept Pharmacol, Tehran, Iran
[6] Univ Tehran Med Sci, Sch Med, Dept Microbiol, Keshavarz Blvd,100 Poursina Ave, Tehran, Iran
关键词
burn infection; curcumin; nanoethosom; silver sulfadiazine; wound healing;
D O I
10.1055/s-0042-114034
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
Background: Curcumin is well known in biomedical investigations with an extensive antimicrobial properties and wound repair effect. However, clinical criteria recommend curcumin should be formulated for topical medication. Material and method: In this study, we prepared Ethosomal curcumin (Etho-cur) formulation for wound healing and bacterial flora assessments in treated rats which were subjected to second degree burn under a standard procedure. Results: Applying once daily of Etho-cur (0.2%) topically on rat's dorsal for 14 days significantly recovered main aspects of wound repair including re-epithelization (P<0.01), neovascularization (P<0.01), collagen synthesis (P<0.001), granulation tissue formation (P<0.001) compared with control. Considerable wound contraction was occurred by Etho-cur treatment sooner than other groups and after 16 days it was completed with a significant (P<0.001) value. Furthermore, ethosomal formulation of curcumin similar to silver sulfadiazine (SSD) cream 1% potentially inhibited (P<0.001) growth of the burn bacterial flora including Pseudomonas aeruginosa as predominant bacteria among experimental isolations during 14 days treatment. Also, antibacterial activity of Etho-cur was estimated approximately 11% more potent than free curcumin in reduction of the burn bacterial flora. Conclusion: Regarding the results, ethosomal curcumin efficiently fights against wound infection and promotes wound repair in burn injuries in rats.
引用
收藏
页码:660 / 665
页数:6
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