REDUCTION OF WHOLE-BLOOD SEROTONIN IN DEPRESSED-PATIENTS TREATED WITH A NEW, SELECTIVE SEROTONIN-UPTAKE INHIBITOR, FEMOXETINE

被引：19
作者：
BORUP, C
PETERSEN, IM
LEFEVREHONORE, P
WETTERBERG, L
机构：
[1] AS FERROSAN, DEPT CLIN, SYDMARKEN 5, DK-2860 Soborg, DENMARK
[2] ST GORANS HOSP, KAROLINSKA INST, DEPT PSYCHIAT, S-11281 STOCKHOLM, SWEDEN
[3] ST HANS MENTAL HOSP, DEPT F, DK-4000 ROSKILDE, DENMARK
来源：
PSYCHOPHARMACOLOGY | 1979年 / 63卷 / 03期
关键词：
5-HT-Uptake inhibition; Antidepressant effect; Femoxetine; Thrombocytes;
D O I：
10.1007/BF00433556
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Femoxetine, a phenylpiperidine derivative with potent serotonin (5-HT)-uptake inhibitory properties, was studied in 12 depressive patients for its clinical effect and its effect on 5-HT concentration in whole blood. The global evaluation after 6 wk showed a good effect in 6 patients. The 5-HT concentration was reduced from a mean value of 0.21 to about 0.05 .mu.g/ml, indicating a total depletion of 5-HT from the thrombocytes. The steady-state concentrations of femoxetine reduced 5-HT to the same level in all patients. No correlation between degree of 5-HT reduction and therapeutic effect was found.
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页码：241 / 243
页数：3
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