IMPAIRED INDUCTION OF ORNITHINE DECARBOXYLASE ACTIVITY FOLLOWING NERVE CRUSH IN THE STREPTOZOTOCIN-DIABETIC RAT

被引：12

作者：

MCLEAN, WG

CHAPMAN, JE

CULLUM, NA

机构：

[1] Department of Pharmacology and Therapeutics, University of Liverpool, Liverpool

来源：

DIABETOLOGIA | 1987年 / 30卷 / 12期

关键词：

diabetes mellitus; nerve regeneration; neuropathy; ornithine decarboxylase; Streptozotocin;

D O I：

10.1007/BF00295882

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Ornithine decarboxylase activity was measured in the dorsal root ganglia from crushed and uncrushed contralateral sciatic nerve of control and streptozotocin-diabetic rats. A further group of diabetic rats was treated with insulin throughout the experiment. Ornithine decarboxylase activity in ganglia from uncrushed nerves was the same in diabetic and non-diabetic rats. A significant (greater than 4-fold) increase in mean levels of ornithine decarboxylase activity 72 h after crush injury was found in ganglia from crushed nerves in non-diabetic but not in diabetic rats. The enzyme activity in ganglia from diabetic rats treated with insulin resembled that in non-diabetic rats. Twenty-four hours after crush injury, ornithine decarboxylase activity in ganglia from crushed nerves was higher in non-diabetic than in diabetic animals. This may be responsible for the delayed and defective nerve regeneration known to occur in peripheral nerve of the streptozotocin-diabetic rat. © 1987 Springer-Verlag.

引用

页码：963 / 965

页数：3

共 11 条

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[2]

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[3] RETROGRADELY TRANSPORTED NERVE GROWTH-FACTOR INCREASES ORNITHINE DECARBOXYLASE ACTIVITY IN RAT SUPERIOR CERVICAL-GANGLIA [J].