HEPOXILINS - A REVIEW ON THEIR ENZYMATIC FORMATION, METABOLISM AND CHEMICAL SYNTHESIS

被引:43
作者
PACEASCIAK, CR [1 ]
REYNAUD, D [1 ]
DEMIN, PM [1 ]
机构
[1] UNIV TORONTO, FAC MED, DEPT PHARMACOL, TORONTO, ON M5S 1A8, CANADA
关键词
D O I
10.1007/BF02538262
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
This article reviews published evidence describing the enzymatic and nonenzymatic formation and the routes of metabolism of the hepoxilins. Also treated are the major approaches used for the chemical synthesis of these compounds and for some of their analogs.
引用
收藏
页码:107 / 114
页数:8
相关论文
共 57 条
  • [1] PRODUCTS OF HEME-CATALYZED TRANSFORMATION OF THE ARACHIDONATE DERIVATIVE 12-HPETE OPEN S-TYPE K+-CHANNELS IN APLYSIA
    BELARDETTI, F
    CAMPBELL, WB
    FALCK, JR
    DEMONTIS, G
    ROSOLOWSKY, M
    [J]. NEURON, 1989, 3 (04) : 497 - 505
  • [2] HEPOXILINS-B-3 - SYNTHESIS OF ALL 4 STEREOISOMERS AND A GLUTATHIONE ADDUCT
    BELOSLUDTSEV, YY
    KOLLAH, RO
    FALCK, JR
    CAPDEVILA, JH
    [J]. TETRAHEDRON LETTERS, 1994, 35 (30) : 5327 - 5330
  • [3] Bryant R W, 1980, Adv Prostaglandin Thromboxane Res, V6, P95
  • [4] ISOLATION OF A NEW LIPOXYGENASE METABOLITE OF ARACHIDONIC-ACID, 8,11,12-TRIHYDROXY-5,9,14-EICOSATRIENOIC ACID FROM HUMAN PLATELETS
    BRYANT, RW
    BAILEY, JM
    [J]. PROSTAGLANDINS, 1979, 17 (01): : 9 - 18
  • [5] FORMATION AND ELECTROPHYSIOLOGICAL ACTIONS OF THE ARACHIDONIC ACID METABOLITES, HEPOXILINS, AT NANOMOLAR CONCENTRATIONS IN RAT HIPPOCAMPAL SLICES
    CARLEN, PL
    GUREVICH, N
    ZHANG, L
    WU, PH
    REYNAUD, D
    PACEASCIAK, CR
    [J]. NEUROSCIENCE, 1994, 58 (03) : 493 - 502
  • [6] ACTIONS OF ARACHIDONIC-ACID AND HEPOXILIN-A3 ON MAMMALIAN HIPPOCAMPAL CA1 NEURONS
    CARLEN, PL
    GUREVICH, N
    WU, PH
    SU, WG
    COREY, EJ
    PACEASCIAK, CR
    [J]. BRAIN RESEARCH, 1989, 497 (01) : 171 - 176
  • [7] SYNTHESIS OF (+/-)-HEPOXILIN-A3 UTILIZING ARSONIUM YLIDES
    CHABERT, P
    MIOSKOWSKI, C
    FALCK, JR
    [J]. TETRAHEDRON LETTERS, 1989, 30 (19) : 2545 - 2548
  • [8] (8-R)-HEPOXILIN-A3 AND (8-S)-HEPOXILIN-A3 - ASSIGNMENT OF CONFIGURATION AND CONVERSION TO BIOLOGICALLY-ACTIVE CONJUGATES WITH GLUTATHIONE
    COREY, EJ
    SU, WG
    [J]. TETRAHEDRON LETTERS, 1990, 31 (15) : 2113 - 2116
  • [9] TOTAL SYNTHESIS OF BIOLOGICALLY-ACTIVE METABOLITES OF ARACHIDONIC-ACID - THE 2 8-HYDROXY-11,12(S,S)-EPOXYEICOSA-5,14(Z),9(E)-TRIENOIC ACIDS
    COREY, EJ
    SU, WG
    [J]. TETRAHEDRON LETTERS, 1984, 25 (45) : 5119 - 5122
  • [10] TOTAL SYNTHESIS OF 12-(S)-10-HYDROXY-TRANS-11,12-EPOXYEICOSA-5,9,14-(Z)-TRIENOIC ACIDS, METABOLITES OF ARACHIDONIC-ACID IN MAMMALIAN BLOOD-PLATELETS
    COREY, EJ
    KANG, J
    LAGUZZA, BC
    JONES, RL
    [J]. TETRAHEDRON LETTERS, 1983, 24 (45) : 4913 - 4916