BLOCKADE OF FEEDING INHIBITION BY NEUROMEDIN-B USING A SELECTIVE RECEPTOR ANTAGONIST

被引：32

作者：

LADENHEIM, EE

TAYLOR, JE

COY, DH

MORAN, TH

机构：

[1] JOHNS HOPKINS UNIV, SCH MED, DEPT PSYCHIAT & BEHAV SCI, BALTIMORE, MD 21205 USA

[2] BIOMEASURE INC, MILFORD, MA 01757 USA

[3] TULANE UNIV, SCH MED, PEPTIDE RES LABS, NEW ORLEANS, LA 70112 USA

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1994年 / 271卷 / 01期

关键词：

NEUROMEDIN B; GASTRIN-RELEASING PEPTIDE; BOMBESIN;

D O I：

10.1016/0014-2999(94)90291-7

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The ability of a selective neuromedin B receptor antagonist, D-Nal-cyclo[Cys-Tyr-D-Trp-Orn-Val-Cys]-Nal-NH2 (BIM-23127), to block suppression of food intake produced by the mammalian bombesin-like peptides neuromedin B and neuromedin C was examined. BIM-23127 completely blocked suppression of intake produced by neuromedin B but not by neuromedin C. These results suggest an independent role for neuromedin B receptors in suppression of food intake by bombesin-like peptides and demonstrate the utility of this group of antagonists for in vivo experiments.

引用

页码：R7 / R9

页数：3

共 7 条

[1] 4TH VENTRICULAR INJECTION OF SELECTIVE BOMBESIN RECEPTOR ANTAGONISTS FACILITATES FEEDING IN RATS [J].