Increased serum gamma-glutamyltransferase activity in patients with metabolic syndrome

被引：23

作者：

Bozbas, Huseyin ^{[1
]}

Yildirir, Aylin ^{[1
]}

Karacaglar, Emir ^{[1
]}

Demir, Ozlem ^{[1
]}

Ulus, Taner ^{[1
]}

Eroglu, Serpil ^{[1
]}

Aydinalp, Alp ^{[1
]}

Ozin, Bulent ^{[1
]}

Muderrisoglu, Haldun ^{[1
]}

机构：

[1] Baskent Univ, Fac Med, Dept Cardiol, Ankara, Turkey

来源：

TURK KARDIYOLOJI DERNEGI ARSIVI-ARCHIVES OF THE TURKISH SOCIETY OF CARDIOLOGY | 2011年 / 39卷 / 02期

关键词：

Biological markers/blood; gamma-glutamyltransferase/blood; inflammation; metabolic syndrome X; oxidative stress;

D O I：

10.5543/tkda.2011.01205

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objectives: Accumulating data indicate that serum gammaglutamyltransferase (GGT) activity represents a true marker of atherosclerotic cardiovascular disease and has prognostic importance. In this study, we sought to evaluate serum GGT activity in patients with metabolic syndrome (MetS). Study design: We enrolled 232 patients (mean age 60.4 years) from our outpatient cardiology clinic, 117 with and 115 without MetS (control group) as defined by the ATP-III criteria. The results of serum liver function tests including serum GGT and C-reactive protein (CRP) levels were compared between the two groups. Results: The two groups were similar with regard to age, sex, smoking, and family history of coronary artery disease (p> 0.05). The prevalences of hypertension and dyslipidemia were significantly higher in patients with MetS. Compared with controls, patients with MetS had significantly higher serum GGT [(median 21, interquartile range (16-33) vs. 19 (14-26) U/l; p=0.008] and C-reactive protein levels [6.2 (3.69.4) vs. 5.0 (3.1-7.0) U/l; p=0.044]. A high GGT activity (> 40 U/l) was determined in 14.5% of the patients with MetS and in 4.4% of the control subjects (p=0.012). Serum GGT level showed significant correlations with MetS (r=0.24, p=0.001), CRP (r=0.20, p=0.003), triglyceride (r=0.18, p=0.006), HDL cholesterol (r=-0.19, p=0.004), aspartate aminotransferase (r=0.15, p=0.02), alanine aminotransferase (r=0.32, p=0.001), and alkaline phosphatase (r=0.16, p=0.01). This significant association continued only for MetS (beta=-0.25, p=0.03), HDL cholesterol (beta=-0.18, p=0.03), and alkaline phosphatase (beta=0.17, p=0.01) in multivariate regression analysis. Conclusion: Our findings suggest that patients with MetS have higher serum GGT and CRP levels compared with controls. This increased GGT level might be a marker of increased oxidative stress and premature atherosclerosis.

引用

页码：122 / 128

页数：7

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