ADAPTIVE RESPONSE TO IONIZING-RADIATION IN NORMAL HUMAN SKIN FIBROBLASTS - ENHANCEMENT OF DNA-REPAIR RATE AND MODULATION OF GENE-EXPRESSION

被引：17
|
作者：
AZZAM, E
DETOLEDO, SM
RAAPHORST, GP
MITCHEL, REJ
机构：
[1] ATOM ENERGY CANADA LTD, CHALK RIVER LABS, CHALK RIVER, ON K0J 1P0, CANADA
[2] UNIV OTTAWA, BIOL SECT, OTTAWA K1N 6N5, ON, CANADA
来源：
JOURNAL DE CHIMIE PHYSIQUE ET DE PHYSICO-CHIMIE BIOLOGIQUE | 1994年 / 91卷 / 7-8期
关键词：
D O I：
10.1051/jcp/1994910931
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Low doses and dose rates of ionizing radiation enhance the rate of DNA repair in human fibroblasts and protect the cells against radiation-induced micronucleus formation. Chronic exposures reduce the mRNA levels of the genes topoisomerase II and FACC-1 (Fanconi's anemia, group C).
引用
收藏
页码：931 / 936
页数：6
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