INEFFICACY OF FRESH-FROZEN PLASMA IN THE TREATMENT OF L-ASPARAGINASE-INDUCED COAGULATION-FACTOR DEFICIENCIES DURING ALL INDUCTION THERAPY

被引：0

作者：

NOWAKGOTTL, U ^{[1
]}

RATH, B ^{[1
]}

BINDER, M ^{[1
]}

HASSEL, JU ^{[1
]}

WOLFF, J ^{[1
]}

HUSEMANN, S ^{[1
]}

RITTER, J ^{[1
]}

机构：

[1] UNIV HOSP MUNSTER,CTR PEDIAT HEMATOL & ONCOL,MUNSTER,GERMANY

来源：

HAEMATOLOGICA | 1995年 / 80卷 / 05期

关键词：

FRESH FROZEN PLASMA; FIBRINOGEN; ANTITHROMBIN; THROMBIN GENERATION; D-DIMER FORMATION;

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A prospective longitudinal study was conducted to determine whether single-donor fresh frozen plasma (FFP) substitution was able to influence L-asparaginase-associated hypoproteinemia. Within a 36-month period, 20 of 42 children with ALL received a total of 42 prophylactic FFP doses at a median of 10 (5-20) mL/kg when fibrinogen levels decreased to < 60 mg/dL, and thrombin time was lengthened. Laboratory monitoring before, during and after FFP substitution showed no shortterm improvements and demonstrated only a minimal increase in fibrinogen and alpha(2)-antiplasmin. Plasma levels of antithrombin and plasminogen remained unchanged. Furthermore, administration of FFP had no influence on thrombin generation, the plasmin/alpha(2)-antiplasmin complex or enhanced D-dimer formation.

引用

页码：451 / 453

页数：3