Omalizumab and treatment-resistant chronic spontaneous urticaria

被引：3

作者：

Akyol, Aynur ^{[1
]}

Oktem, Ayse ^{[1
]}

Akay, Bengu Nisa ^{[1
]}

Kundakci, Nihal ^{[1
]}

Boyvat, Ayse ^{[1
]}

机构：

[1] Ankara Univ, Tip Fak, Deri & Zuhrevi Hastaliklar Anabilim Dali, TR-06100 Ankara, Turkey

来源：

TURKDERM-TURKISH ARCHIVES OF DERMATOLOGY AND VENEROLOGY | 2015年 / 49卷 / 03期

关键词：

Chronic spontaneous urticaria; chronic urticaria; omalizumab; anti-IgE; treatment;

D O I：

10.4274/turkderm.22587

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Background and Design: Humanized monoclonal antibody omalizumab was developed for the treatment of moderate-to-severe asthma. However, recently, reports on the successful use of omalizumab in the treatment of resistant chronic urticaria are increasing in the literature. Materials and Methods: We retrospectively evaluated treatment response, adverse effects and duration of remission in 13 chronic spontaneous urticaria patients treated with omalizumab between May 2010 and January 2014. Results: In ten of the thirteen patients treated with omalizumab, urticarial lesions were suppressed and no side effects were observed. Conclusion: Our observations support the findings in the literature indicating that omalizumab is an effective and safe option in the management of treatment-resistant chronic urticaria.

引用

页码：180 / 183

页数：4

共 27 条

[1] IgE Mediated Autoallergy against Thyroid Peroxidase - A Novel Pathomechanism of Chronic Spontaneous Urticaria? [J].

Altrichter, Sabine ;

Peter, Hans-Juergen ;

Pisarevskaja, Dina ;

Metz, Martin ;

Martus, Peter ;

Maurer, Marcus .

PLOS ONE, 2011, 6 (04)

[2] Omalizumab, a novel anti-IgE therapy in allergic disorders [J].

Babu, KS ;

Arshad, SH ;

Holgate, ST .

EXPERT OPINION ON BIOLOGICAL THERAPY, 2001, 1 (06) :1049-1058

[3] Successful treatment of cold-induced urticaria/anaphylaxis with anti-IgE [J].

Boyce, Joshua A. .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2006, 117 (06) :1415-1418

[4] Omalizumab markedly improves urticaria activity scores and quality of life scores in chronic spontaneous urticaria patients: A real life survey [J].

Buyukozturk, Suna ;

Gelincik, Asli ;

Demirturk, Mustafa ;

Kocaturk, Emek ;

Colakoglu, Bahattin ;

Dal, Murat .

JOURNAL OF DERMATOLOGY, 2012, 39 (05) :439-442

[5] Omalizumab is effective in nonautoimmune urticaria [J].

Ferrer, Marta ;

Gamboa, Pedro ;

Sanz, Maria L. ;

Goikoetxea, Maria Jose ;

Cabrera-Freitag, Paula ;

Javaloyes, Gracia ;

Berroa, Felicia ;

Kaplan, Allen P. .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2011, 127 (05) :1300-1302

[6] Omalizumab in severe chronic urticaria [J].

Godse, K. V. .

INDIAN JOURNAL OF DERMATOLOGY VENEREOLOGY & LEPROLOGY, 2008, 74 (02) :157-158

[7] Successful treatment of solar urticaria with anti-immunoglobulin E therapy [J].

Guezelbey, O. ;

Ardelean, E. ;

Magerl, M. ;

Zuberbier, T. ;

Maurer, M. ;

Metz, M. .

ALLERGY, 2008, 63 (11) :1563-1565

[8] The anti-inflammatory effects of omalizumab confirm the central role of IgE in allergic inflammation [J].

Holgate, S ;

Casale, T ;

Wenzel, S ;

Bousquet, J ;

Deniz, Y ;

Reisner, C .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2005, 115 (03) :459-465

[9] The use of omalizumab in the treatment of severe allergic asthma: A clinical experience update [J].

Holgate, Stephen ;

Buhl, Roland ;

Bousquet, Jean ;

Smith, Nicola ;

Panahloo, Zoya ;

Jimenez, Pablo .

RESPIRATORY MEDICINE, 2009, 103 (08) :1098-1113

[10] Omalizumab for Chronic Urticaria: A Case Series and Overview of the Literature [J].

Ivyanskiy, Ilya ;

Sand, Carsten ;

Thomsen, Simon Francis .

CASE REPORTS IN DERMATOLOGY, 2012, 4 (01) :19-26

← 1 2 3 →