IMIDAZO[1,2-B]PYRIDAZINES .13. SYNTHESES AND CENTRAL-NERVOUS-SYSTEM ACTIVITIES OF SOME 2-BENZYL(PHENETHYL, BIPHENYL-4'-YL, 6'-METHYLNAPHTHALEN-2'-YL, TERT-BUTYL AND CYCLOHEXYL)-3-METHOXY(ACYLAMINOMETHYL AND DIMETHYLAMINOMETHYL)-6-(VARIOUSLY SUBSTITUTED)IMIDAZO[1,2-B]PYRIDAZINES

被引：7
作者：
BARLIN, GB [1 ]
DAVIES, LP [1 ]
IRELAND, SJ [1 ]
ZHANG, JK [1 ]
机构：
[1] AUSTRALIAN NATL UNIV,RES SCH BIOL SCI,VISUAL SCI GRP,CANBERRA,ACT 2601,AUSTRALIA
来源：
AUSTRALIAN JOURNAL OF CHEMISTRY | 1992年 / 45卷 / 08期
关键词：
D O I：
10.1071/CH9921281
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
6-(Variously substituted)-3-methoxy(unsubstituted, dimethylaminomethyl, acetamidomethyl and benzamidomethyl)-2-benzyl(phenethyl, biphenyl-4'-yl, 6'-methylnaphthalen-2'-yl, t-butyl and cyclohexyl)imidazo[1,2-b]pyridazines have been prepared and examined for activity in the central nervous system. Of these, 2-benzyl-3-methoxy-6-(3'-methoxybenzylamino)imidazo[1,2-b) pyridazine (IC50 88 nm) bound most strongly to rat brain membrane. In general, the order of activity for group sat the 2-position was Ph > PhCH2 > PhCH2CH2 > C6H4Ph-p, 6'-methylnaphthalen-2'-yl, c-C6H11 or Bu(t).
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页码：1281 / 1300
页数：20
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