SUBSTANCE-P IN RAT CORNEAL AND IRIDAL NERVES - AN ULTRASTRUCTURAL IMMUNOHISTOCHEMICAL STUDY

被引：33

作者：

BECKERS, HJM ^{[1
]}

KLOOSTER, J ^{[1
]}

VRENSEN, GFJM ^{[1
]}

LAMERS, WPMA ^{[1
]}

机构：

[1] UNIV LIMBURG,DEPT OPHTHALMOL,6200 MD MAASTRICHT,NETHERLANDS

来源：

OPHTHALMIC RESEARCH | 1993年 / 25卷 / 03期

关键词：

SUBSTANCE-P; CALCITONIN GENE-RELATED PEPTIDE; CORNEA; IRIS; IMMUNOHISTOCHEMISTRY;

D O I：

10.1159/000267291

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

The distribution of substance P (SP) within the nerve fibers of the rat cornea and iris was studied using electron microscopic immunohistochemistry. Numerous SP-immunoreactive fibers were found throughout the corneal and iridal stroma. The most intense staining was found within varicosities containing numerous vesicles. Similar SP-immunoreactive varicosities were found in fibers in close proximity to the iris sphincter and dilator muscles. On account of previous ultrastructural work the SP-containing fibers and varicosities must be assumed to be of trigeminal origin. Additionally, the distribution of SP and calcitonin gene-related peptide (CGRP) in corneal and iridal fibers of rats is similar, suggesting that CGRP and SP are colocalized and may be coreleased from the same varicosities.

引用

页码：192 / 200

页数：9

共 16 条

[1]

BECKERS HJM, 1992, INVEST OPHTH VIS SCI, V33, P1979

[2] ULTRASTRUCTURAL EVIDENCE FOR THE COEXISTENCE OF CALCITONIN GENE-RELATED PEPTIDE AND SUBSTANCE-P IN SECRETORY VESICLES OF PERIPHERAL-NERVES IN THE GUINEA-PIG [J].

GULBENKIAN, S ;

MERIGHI, A ;

WHARTON, J ;

VARNDELL, IM ;

POLAK, JM .

JOURNAL OF NEUROCYTOLOGY, 1986, 15 (04) :535-542

[3] CALCITONIN GENE-RELATED PEPTIDE IN THE NERVOUS-TISSUE [J].

ISHIDAYAMAMOTO, A ;

TOHYAMA, M .

PROGRESS IN NEUROBIOLOGY, 1989, 33 (5-6) :335-+

[4]

KUWAYAMA Y, 1987, INVEST OPHTH VIS SCI, V28, P1947

[5] COEXISTENCE OF CALCITONIN GENE-RELATED PEPTIDE AND SUBSTANCE-P-LIKE PEPTIDE IN SINGLE CELLS OF THE TRIGEMINAL GANGLION OF THE RAT - IMMUNOHISTOCHEMICAL ANALYSIS [J].

LEE, Y ;

KAWAI, Y ;

SHIOSAKA, S ;

TAKAMI, K ;

KIYAMA, H ;

HILLYARD, CJ ;

GIRGIS, S ;

MACINTYRE, I ;

EMSON, PC ;

TOHYAMA, M .

BRAIN RESEARCH, 1985, 330 (01) :194-196

[6]

MARFURT CF, 1989, INVEST OPHTH VIS SCI, V30, P461

[7] CORNEAL SENSORY PATHWAY IN THE RAT - A HORSERADISH-PEROXIDASE TRACING STUDY [J].

MARFURT, CF ;

DELTORO, DR .

JOURNAL OF COMPARATIVE NEUROLOGY, 1987, 261 (03) :450-459

[8] SUBSTANCE-P IMMUNOREACTIVE SENSORY NERVES SUPPLY THE RAT IRIS AND CORNEA [J].

MILLER, A ;

COSTA, M ;

FURNESS, JB ;

CHUBB, IW .

NEUROSCIENCE LETTERS, 1981, 23 (03) :243-249

[9]

POL AN, 1986, J COMP NEUROL, V52, P507

[10] A DIRECT CONTACT OF SUBSTANCE-P-CONTAINING NERVE-FIBERS WITH PUPILLARY SPHINCTER MUSCLES OF THE RAT - AN IMMUNOHISTOCHEMICAL ANALYSIS [J].

SHIMIZU, Y ;

ISHIMOTO, I ;

SHIOSAKA, S ;

KUWAYAMA, Y ;

FUKUDA, M ;

INAGAKI, S ;

SAKANAKA, M ;

TOHYAMA, M .

NEUROSCIENCE LETTERS, 1982, 33 (01) :25-28

← 1 2 →