SUBSTANCE-P IN RAT CORNEAL AND IRIDAL NERVES - AN ULTRASTRUCTURAL IMMUNOHISTOCHEMICAL STUDY

被引：32
作者：
BECKERS, HJM [1 ]
KLOOSTER, J [1 ]
VRENSEN, GFJM [1 ]
LAMERS, WPMA [1 ]
机构：
[1] UNIV LIMBURG,DEPT OPHTHALMOL,6200 MD MAASTRICHT,NETHERLANDS
来源：
OPHTHALMIC RESEARCH | 1993年 / 25卷 / 03期
关键词：
SUBSTANCE-P; CALCITONIN GENE-RELATED PEPTIDE; CORNEA; IRIS; IMMUNOHISTOCHEMISTRY;
D O I：
10.1159/000267291
中图分类号：
R77 [眼科学];
学科分类号：
100212 ;
摘要：
The distribution of substance P (SP) within the nerve fibers of the rat cornea and iris was studied using electron microscopic immunohistochemistry. Numerous SP-immunoreactive fibers were found throughout the corneal and iridal stroma. The most intense staining was found within varicosities containing numerous vesicles. Similar SP-immunoreactive varicosities were found in fibers in close proximity to the iris sphincter and dilator muscles. On account of previous ultrastructural work the SP-containing fibers and varicosities must be assumed to be of trigeminal origin. Additionally, the distribution of SP and calcitonin gene-related peptide (CGRP) in corneal and iridal fibers of rats is similar, suggesting that CGRP and SP are colocalized and may be coreleased from the same varicosities.
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收藏
页码：192 / 200
页数：9
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