SEPARATION AND ESTIMATION OF SMALL AMOUNTS OF THE ENANTIOMERS OF CARBIDOPA AND METHYLDOPA ON A CHIRAL STATIONARY PHASE WITH L-PHENYLALANINE AS SELECTOR IN LIGAND-EXCHANGE CHROMATOGRAPHY

被引：5

作者：

LAUSECKER, B ^{[1
]}

ALBERT, FM ^{[1
]}

机构：

[1] CENT INST ORGAN CHEM,DEPT CENT ANALYT,W-1199 BERLIN,GERMANY

来源：

JOURNAL OF CHROMATOGRAPHY | 1991年 / 545卷 / 01期

关键词：

D O I：

10.1016/S0021-9673(01)88700-8

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

The chiral stationary phase with L-phenylalanine as selector was used for the separation of the enantiomers of carbidopa and methyldopa in ligand-exchange chromatography. The influence of pH, organic modifier and copper(II) salt concentration in the eluent on capacity and separation factors has been shown. The applicability of this method to the detection of small amounts of S-methyldopa and R-carbidopa in S-carbidopa has been demonstrated.

引用

页码：115 / 122

页数：8

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