ORIENTATION OF HERPES-SIMPLEX VIRUS TYPE-1 IMMEDIATE EARLY MESSENGER-RNAS

被引：75

作者：

CLEMENTS, JB ^{[1
]}

MCLAUCHLAN, J ^{[1
]}

MCGEOCH, DJ ^{[1
]}

机构：

[1] UNIV GLASGOW,INST VIROL,MRC,VIROL UNIT,GLASGOW G11 5JR,SCOTLAND

来源：

NUCLEIC ACIDS RESEARCH | 1979年 / 7卷 / 01期

关键词：

D O I：

10.1093/nar/7.1.77

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We have determined the orientation of 4 immediate early (IE) mRNA's on the herpes simplex virus type 1 genome by mapping cDNA's complementary to the 3′-termini of messages. These IE mRNA's are transcribed by a pre-existing cell RNA polymerase, and we propose a model which allows their synthesis from a circular template using a single virus promoter region. The promoter region, which is located in the two repetitive DNA regions which flank the short unique region of the virus genome, may serve to initiate bidirectional transcription of these IE mRNA's. © 1979 Information Retrieval Limited.

引用

页码：77 / 91

页数：15

共 23 条

[1] ANALYSIS OF HERPESVIRUS DNA SUBSTRUCTURE BY MEANS OF RESTRICTION ENDONUCLEASES [J].

CLEMENTS, JB ;

CORTINI, R ;

WILKIE, NM .

JOURNAL OF GENERAL VIROLOGY, 1976, 30 (FEB) :243-256

[2]

CLEMENTS JB, 1977, CELL, V12, P275

[3] EVIDENCE THAT HERPES-SIMPLEX VIRUS-DNA IS TRANSCRIBED BY CELLULAR RNA POLYMERASE-B [J].

COSTANZO, F ;

CAMPADELLIFIUME, G ;

FOATOMASI, L ;

CASSAI, E .

JOURNAL OF VIROLOGY, 1977, 21 (03) :996-1001

[4]

DAVISON A, UNPUBLISHED

[5]

HAY RW, UNPUBLISHED

[6] ANATOMY OF HERPES-SIMPLEX VIRUS DNA - EVIDENCE FOR 4 POPULATIONS OF MOLECULES THAT DIFFER IN RELATIVE ORIENTATIONS OF THEIR LONG AND SHORT COMPONENTS .4. [J].

HAYWARD, GS ;

JACOB, RJ ;

WADSWORTH, SC ;

ROIZMAN, B .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1975, 72 (11) :4243-4247

[7] REGULATION OF HERPESVIRUS MACROMOLECULAR-SYNTHESIS - SEQUENTIAL TRANSITION OF POLYPEPTIDE-SYNTHESIS REQUIRES FUNCTIONAL VIRAL POLYPEPTIDES .3. [J].

HONESS, RW ;

ROIZMAN, B .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1975, 72 (04) :1276-1280

[8] VIRUS SPECIFIED ENZYME-ACTIVITY AND RNA SPECIES IN HERPES-SIMPLEX VIRUS TYPE-1 TRANSFORMED MOUSE CELLS [J].

JAMIESON, AT ;

MACNAB, JCM ;

PERBAL, B ;

CLEMENTS, JB .

JOURNAL OF GENERAL VIROLOGY, 1976, 32 (SEP) :493-508

[9] APPEARANCE INVIVO OF SINGLE-STRANDED COMPLEMENTARY ENDS ON PARENTAL HERPESVIRUS DNA [J].

JEAN, JH ;

BENPORAT, T .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1976, 73 (08) :2674-2678

[10] ANATOMY OF HERPES-SIMPLEX VIRUS-DNA .7. ALPHA-RNA IS HOMOLOGOUS TO NON-CONTIGUOUS SITES IN BOTH L AND S COMPONENTS OF VIRAL-DNA [J].

JONES, PC ;

HAYWARD, GS ;

ROIZMAN, B .

JOURNAL OF VIROLOGY, 1977, 21 (01) :268-276

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