BRADYKININ-LIKE IMMUNOREACTIVE NEURONAL SYSTEMS LOCALIZED HISTOCHEMICALLY IN RAT-BRAIN

被引：172

作者：

CORREA, FMA

INNIS, RB

UHL, GR

SNYDER, SH

机构：

[1] JOHNS HOPKINS UNIV, SCH MED, DEPT PHARMACOL, BALTIMORE, MD 21205 USA

[2] JOHNS HOPKINS UNIV, SCH MED, DEPT EXPTL THERAPEUT, BALTIMORE, MD 21205 USA

[3] JOHNS HOPKINS UNIV, SCH MED, DEPT PSYCHIAT, BALTIMORE, MD 21205 USA

[4] JOHNS HOPKINS UNIV, SCH MED, DEPT BEHAV SCI, BALTIMORE, MD 21205 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1979年 / 76卷 / 03期

关键词：

D O I：

10.1073/pnas.76.3.1489

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Bradykinin-like immunoreactive structures were localized in rat brain by the indirect immunofluorescence method. Specificity of staining was demonstrated by: (i) the absence of fluorescence when preimmune serum was used, (ii) the disappearance of fluorescence when sera were preadsorbed with bradykinin, and (iii) the presence of identical staining with two different antisera. Immunoreactive neuronal cells are observed only in the hypothalamus, with especially dense clusters overlying the periventricular and dorsomedial nuclei. Fibers and varicose processes are observed in the periaqueductal gray matter, hypothalamus, perirhinal and cingulate cortices, the ventral portion of caudate-putamen and the lateral septal area.

引用

页码：1489 / 1493

页数：5

共 21 条

[1]

COONS AH, 1958, GENERAL CYTOCHEMICAL, P399

[2]

CORRADO AP, 1976, CIENC CULT-SAO PAULO, V26, P589

[3] CENTRAL MECHANISMS OF HYPERTENSIVE ACTION OF INTRAVENTRICULAR BRADYKININ IN UNANESTHETIZED RAT [J].