NALOXONE-PRECIPITATED MORPHINE-WITHDRAWAL INCREASES PONTINE GLUTAMATE LEVELS IN THE RAT

被引:63
作者
ZHANG, TS [1 ]
FENG, YZ [1 ]
ROCKHOLD, RW [1 ]
HO, IK [1 ]
机构
[1] UNIV MISSISSIPPI, MED CTR, DEPT PHARMACOL & TOXICOL, JACKSON, MS 39216 USA
关键词
GLUTAMATE; LOCUS COERULEUS; MORPHINE WITHDRAWAL; MICRODIALYSIS;
D O I
10.1016/0024-3205(94)90108-2
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Extracellular fluid (ECF) levels of glutamate (Glu) and aspartate (Asp) were measured in the locus coeruleus (LC) during morphine withdrawal by using microdialysis in conscious morphine-dependent Sprague-Dawley rats. Guide cannulae were implanted chronically and rats were given intracerebroventricular (i.c.v.) infusions of morphine (26 nmol/1 mu l/hr) or saline (1 mu l/hr) for 3 days. Microdialysis probes (2 mm tip) were inserted into the LC 24 hr before precipitation of withdrawal by i.c.v. injection of naloxone (12 or 48 nmol/5 mu l). Behavioral evidence of withdrawal (teeth-chattering, wet-dog shakes, etc.) was detected following naloxone challenge in morphine, but not in saline-infused rats. Increases (P<0.01) in ECF levels of Glu (and Asp, to a lesser degree) were noted after naloxone-precipitated withdrawal only in the morphine group. The ECF Glu levels in the LC increased from 9.6 +/- 2.7 to 15.5 +/- 5.0 mu M following 12 nmol/5 mu l naloxone, and from 9.5 +/- 1.9 to 20.5 +/- 3.3 mu M following 48 nmol/5 mu l naloxone, before and in the first 15 min sample after the precipitation of withdrawal in the morphine-dependent rats, respectively. These results provide direct evidence to support the role of excitatory amino acids within the LC in morphine withdrawal.
引用
收藏
页码:PL25 / PL31
页数:7
相关论文
共 13 条
[1]   MORPHINE-INHIBITION OF CALCIUM FLUXES, NEUROTRANSMITTER RELEASE AND PROTEIN AND LIPID PHOSPHORYLATION IN BRAIN-SLICES AND SYNAPTOSOMES [J].
CROWDER, JM ;
NORRIS, DK ;
BRADFORD, HF .
BIOCHEMICAL PHARMACOLOGY, 1986, 35 (15) :2501-2507
[2]   AMINO-ACID NEUROTRANSMITTERS IN POSTMORTEM HUMAN-BRAIN ANALYZED BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY WITH ELECTROCHEMICAL DETECTION [J].
ELLISON, DW ;
BEAL, MF ;
MARTIN, JB .
JOURNAL OF NEUROSCIENCE METHODS, 1987, 19 (04) :305-315
[3]  
ENNIS M, 1988, J NEUROSCI, V8, P3644
[4]   THE PHYSICAL-DEPENDENCE LIABILITY OF BUTORPHANOL - A COMPARATIVE-STUDY WITH MORPHINE [J].
HORAN, P ;
HO, IK .
EUROPEAN JOURNAL OF PHARMACOLOGY, 1991, 203 (03) :387-391
[5]  
PROUDFIT HK, 1988, PROG BRAIN RES, V77, P357
[6]  
RASMUSSEN K, 1991, PROG BRAIN RES, V88, P207
[7]   EXCITATORY AMINO-ACIDS AND MORPHINE-WITHDRAWAL - DIFFERENTIAL-EFFECTS OF CENTRAL AND PERIPHERAL KYNURENIC ACID ADMINISTRATION [J].
RASMUSSEN, K ;
KRYSTAL, JH ;
AGHAJANIAN, GK .
PSYCHOPHARMACOLOGY, 1991, 105 (04) :508-512
[8]   WITHDRAWAL-INDUCED ACTIVATION OF LOCUS COERULEUS NEURONS IN OPIATE-DEPENDENT RATS - ATTENUATION BY LESIONS OF THE NUCLEUS PARAGIGANTOCELLULARIS [J].
RASMUSSEN, K ;
AGHAJANIAN, GK .
BRAIN RESEARCH, 1989, 505 (02) :346-350
[9]   PARAVENTRICULAR NUCLEUS - A SITE FOR THE INTEGRATION OF NEUROENDOCRINE AND AUTONOMIC MECHANISMS [J].
SWANSON, LW ;
SAWCHENKO, PE .
NEUROENDOCRINOLOGY, 1980, 31 (06) :410-417
[10]   GLUTAMATE ANTAGONISTS PREVENT MORPHINE-WITHDRAWAL IN MICE AND GUINEA-PIGS [J].
TANGANELLI, S ;
ANTONELLI, T ;
MORARI, M ;
BIANCHI, C ;
BEANI, L .
NEUROSCIENCE LETTERS, 1991, 122 (02) :270-272