CRYSTAL-STRUCTURE OF THE HHAL DNA METHYLTRANSFERASE COMPLEXED WITH S-ADENOSYL-L-METHIONINE

被引：361

作者：

CHENG, XD ^{[1
]}

KUMAR, S ^{[1
]}

POSFAI, J ^{[1
]}

PFLUGRATH, JW ^{[1
]}

ROBERTS, RJ ^{[1
]}

机构：

[1] NEW ENGLAND BIOLABS INC,BEVERLY,MA 01915

来源：

CELL | 1993年 / 74卷 / 02期

关键词：

D O I：

10.1016/0092-8674(93)90421-L

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The first three-dimensional structure of a DNA methyltransferase is presented. The crystal structure of the DNA (cytosine-5)-methyltransferase, M.Hhal (recognition sequence: GCGC), complexed with S-adenosyl-L-methionine has been determined and refined at 2.5 angstrom resolution. The core of the structure is dominated by sequence motifs conserved among all DNA (cytosine-5)-methyltransferases, and these are responsible for cofactor binding and methyltransferase function.

引用

页码：299 / 307

页数：9

共 50 条

[1] Crystal structure of dengue virus methyltransferase without S-adenosyl-L-methionine
Noble, Christian G.
Li, Shi-Hua
Dong, Hongping
Chew, Sock Hui
Shi, Pei-Yong
ANTIVIRAL RESEARCH, 2014, 111 : 78 - 81
[2] PURIFICATION OF THE KPNI DNA METHYLTRANSFERASE AND PHOTOLABELING OF THE ENZYME WITH S-ADENOSYL-L-METHIONINE
FINTA, C
SULIMA, U
VENETIANER, P
KISS, A
GENE, 1995, 164 (01) : 65 - 69
[3] PHOTOLABELING OF THE ECOP15 DNA METHYLTRANSFERASE WITH S-ADENOSYL-L-METHIONINE
AHMAD, I
RAO, DN
GENE, 1994, 142 (01) : 67 - 71
[4] DIRECT PHOTOLABELING OF THE ECORII METHYLTRANSFERASE WITH S-ADENOSYL-L-METHIONINE
SOM, S
FRIEDMAN, S
JOURNAL OF BIOLOGICAL CHEMISTRY, 1990, 265 (08) : 4278 - 4283
[5] DNA RECOGNITION BY THE ECOK METHYLTRANSFERASE - THE INFLUENCE OF DNA METHYLATION AND THE COFACTOR S-ADENOSYL-L-METHIONINE
POWELL, LM
DRYDEN, DTF
WILLCOCK, DF
PAIN, RH
MURRAY, NE
JOURNAL OF MOLECULAR BIOLOGY, 1993, 234 (01) : 60 - 71
[6] S-Adenosyl-L-methionine:L-methionine S-methyltransferase from germinating barley
Pimenta, MJ
Kaneta, T
Larondelle, Y
Dohmae, N
Kamiya, Y
PLANT PHYSIOLOGY, 1998, 118 (02) : 431 - 438
[7] S-ADENOSYL-L-METHIONINE - CYTISINE METHYLTRANSFERASE IN THERMOPSIS-SEEDLINGS
MURAKOSHI, I
SANDA, A
HAGINIWA, J
SUZUKI, N
OHMIYA, S
OTOMASU, H
CHEMICAL & PHARMACEUTICAL BULLETIN, 1977, 25 (08) : 1970 - 1973
[8] Crystal structure of Streptococcus pneumoniae Sp1610, a putative tRNA methyltransferase, in complex with S-adenosyl-L-methionine
Ta, Hai Minh
Kim, Kyeong Kyu
PROTEIN SCIENCE, 2010, 19 (03) : 617 - 624
[9] Anammox Bacterial S-Adenosyl-l-Methionine Dependent Methyltransferase Crystal Structure and Its Interaction with Acyl Carrier Proteins
Uegaki, Tesshin
Takei, Taisei
Yamaguchi, Shuhei
Fujiyama, Keisuke
Sato, Yusuke
Hino, Tomoya
Nagano, Shingo
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023, 24 (01)
[10] S-ADENOSYL-L-METHIONINE IN A NEUROBLASTOMA
LYON, GM
PEDIATRIC RESEARCH, 1970, 4 (05) : 454 - &

← 1 2 3 4 5 →