MOTHER-TO-CHILD TRANSMISSION OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 - CORRELATION WITH NEUTRALIZING ANTIBODIES AGAINST PRIMARY ISOLATES

被引：176
作者：
SCARLATTI, G
ALBERT, J
ROSSI, P
HODARA, V
BIRAGHI, P
MUGGIASCA, L
FENYO, EM
机构：
[1] KAROLINSKA INST,DEPT IMMUNOL,S-10401 STOCKHOLM 60,SWEDEN
[2] NATL BACTERIOL LAB,DEPT VIROL,S-10521 STOCKHOLM,SWEDEN
[3] UNIV ROMA TOR VERGATA,DEPT PEDIAT,ROME,ITALY
[4] UNITA SOCIO SANIT LOCALE 751,MILAN,ITALY
[5] UNIV MILAN,DEPT GYNECOL & OBSTET 7,I-20122 MILAN,ITALY
来源：
JOURNAL OF INFECTIOUS DISEASES | 1993年 / 168卷 / 01期
关键词：
D O I：
10.1093/infdis/168.1.207
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The aim of this study was to investigate the influence of neutralizing antibodies in mother's serum on the risk of mother-to-child transmission of human immunodeficiency virus type 1 (HIV-1). Sera from 20 HIV-1 infected mothers were analyzed for their ability to neutralize their own virus (autologous neutralization) and virus obtained from other mothers (heterologous neutralization). A statistically significant correlation was found between the capacity to neutralize 1 selected primary isolate and protection of the child from infection. Also, neutralizing antibodies against autologous virus were more frequently present in nontransmitting mothers than in transmitting mothers (5 and 2, respectively, of 10 mothers). The mothers with autologous neutralizing antibodies also neutralized at least 2 heterologous primary isolates. Thus, mothers with neutralizing antibodies to primary HIV-1 isolates have a reduced risk of infecting their children.
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页码：207 / 210
页数：4
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