ENZYMATIC-HYDROLYSIS OF HYDROPHILIC ESTERS BY LIPASES - CARBOXY DEBLOCKING OF PEPTIDES AND GLYCOPEPTIDES

被引：15

作者：

BRAUM, G ^{[1
]}

BRAUN, P ^{[1
]}

KOWALCZYK, D ^{[1
]}

KUNZ, H ^{[1
]}

机构：

[1] UNIV MAINZ,INST ORGAN CHEM,BECHER WEG 18-20,W-6500 MAINZ,GERMANY

来源：

TETRAHEDRON LETTERS | 1993年 / 34卷 / 19期

关键词：

ENZYMATIC PROTECTING GROUP TECHNIQUE; LIPASE-CATALYZED HYDROLYSIS; POLAR ESTERS; PEPTIDES; GLYCOPEPTIDES;

D O I：

10.1016/S0040-4039(00)93392-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The markedly hydrophilic 2-(N-morpholino)ethyl (MoEt) esters of protected peptides and glycopeptides are selectively and efficiently cleaved by lipases in water/acetone (10:1) at pH 7.

引用

页码：3111 / 3114

页数：4

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