HIPPOCAMPAL KINDLING LEADS TO DIFFERENT CHANGES IN PAIRED-PULSE DEPRESSION OF LOCAL EVOKED FIELD POTENTIALS IN CA1 AREA AND IN FASCIA-DENTATA

被引：47

作者：

KAMPHUIS, W ^{[1
]}

GORTER, JA ^{[1
]}

WADMAN, WJ ^{[1
]}

DASILVA, FHL ^{[1
]}

机构：

[1] NETHERLANDS INST BRAIN RES,1095 KJ AMSTERDAM,NETHERLANDS

来源：

NEUROSCIENCE LETTERS | 1992年 / 141卷 / 01期

关键词：

KINDLING; EPILEPSY; FIELD POTENTIAL; INHIBITION; HIPPOCAMPUS; CA1; FASCIA DENTATA;

D O I：

10.1016/0304-3940(92)90344-7

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Monosynaptic evoked field potentials (EPs) in response to paired-pulse stimulation (20 ms interval) were recorded in area CA1 and fascia dentata of the same animal in the course of development of a kindled focus in the CA1 region. A significant reduction of paired pulse depression in response to medium and high stimulation intensity was found in CA1. A similar change was found in the fascia dentata in response to medium intensity stimulation of the angular bundle. In contrast, at high intensity, paired pulse depression was enhanced in the fascia dentata in the course of kindling. These results indicate that kindling epileptogenesis is accompanied by regionally different changes in recurrent inhibition: a reduction in CA1 and intensity dependent changes in fascia dentata.

引用

页码：101 / 105

页数：5

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