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LONG-TERM PROSTACYCLIN - TREATMENT ACTS ON THE DNA AND RNA-CONTENT OF RAT GASTRIC (ANTRAL AND FUNDIC) MUCOSA DOSE-DEPENDENTLY
被引：0
作者：
BALINT, GA
KARACSONY, G
机构：
关键词：
PROSTACYCLIN;
LONG-TERM TREATMENT;
DNA;
RNA;
RAT;
GASTRIC MUCOSA;
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ;
100201 ;
摘要：
The changes in garstric (antral and fundic) mucosal DNA and RNA contents were investigated in long-term (80 days) treatment of rats with orally administered prostacyclin. Prostacyclin caused a dose-dependent, significant increase of the DNA levels in both parts of the gastric mucosa together with a significant thickening of the fundic mucosa. The observed changes (decrease) of the RNA/DNA ratio in the fundic as well as antral mucosa, are interpreted as a sign of accelerated cell renewal, i.e. hyperplasia.
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页码：137 / 141
页数：5
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