NUCLEOTIDES .35. SYNTHESIS OF 3'-DEOXYADENYLYL-(2'-5')-3'-DEOXYADENYLYL-(2'-OMEGA)-9-(OMEGA-HYDROXYALKYL)ADENINES

被引：5
作者：
MIKHAILOV, SN
CHARUBALA, R
PFLEIDERER, W
机构：
[1] UNIV CONSTANCE,FAK CHEM,POSTFACH 5560,W-7750 CONSTANCE,GERMANY
[2] RUSSIAN ACAD SCI,INST MOLEC BIOL,MOSCOW 117984,RUSSIA
来源：
HELVETICA CHIMICA ACTA | 1991年 / 74卷 / 04期
关键词：
D O I：
10.1002/hlca.19910740419
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Via the phosphotriester approach, new structural analogs of (2'-5')oligoadenylates, namely 3'-deoxyadenylyl-(2'-5')-3'-deoxyadenylyl-(2'-omega)-9-(omega-hydroxyalkyl)adenines 18-21, have been synthesized (see Scheme) which should preserve biological activity and show higher stability towards phosphodiesterases. The newly synthesized oligonuleotides 18-21 have been characterized by H-1-NMR spectra, TLC, and HPLC analysis.
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页码：887 / 891
页数：5
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