HISTAMINE H1-RECEPTOR AND H2-RECEPTOR ANTAGONISTS REDUCE HISTAMINE-INDUCED INCREASES IN VASCULAR-PERMEABILITY AND EDEMA FORMATION IN CAT SKELETAL-MUSCLE

Intra-arterial infusions of histamine cause vasodilatation of resistance vessels, extravasation of albumin and oedema in cat skeletal muscle. Treatment with either mepyramine or metiamide significantly reduced the extravasation of albumin and rate of oedema formation. The doses of mepyramine and metiamide used did not modify the vascular responses to bradykinin. © 1979 Birkhäuser Verlag.