A CASE OF CEREBELLAR MEDULLOBLASTOMA WITH A SINGLE CHROMOSOME ABNORMALITY

被引：13
作者：
STRATTON, MR
DARLING, J
COOPER, CS
REEVES, BR
机构：
[1] INST NEUROL,GOUGH COOPER DEPT NEUROL SURG,NEUROONCOL SECT,LONDON WC1N 3BG,ENGLAND
[2] INST CANC RES,CHESTER BEATTY LABS,CHEM CARCINOGENESIS SECT,LONDON,ENGLAND
[3] INST CHILD HLTH,LEUKAEMIA RES FUND,CTR CHILDHOOD LEUKAEMIA,DEPT HAEMATOL & ONCOL,BIRMINGHAM B16 8ET,W MIDLANDS,ENGLAND
来源：
CANCER GENETICS AND CYTOGENETICS | 1991年 / 53卷 / 01期
关键词：
D O I：
10.1016/0165-4608(91)90120-J
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
In the few published karyotypes of human medulloblastoma, multiple chromosome abnormalities have usually been demonstrated. We report a case of medulloblastoma in which only a single structural alteration was observed, namely an unbalanced translocation between chromosomes 1 and 6 resulting in partial 1q trisomy and partial 6q monosomy. This finding may help define genomic regions that are of importance in development of medulloblastoma.
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页码：101 / 103
页数：3
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