Synthesis and Antibacterial Activity of 2-Monolaurin

被引:12
|
作者
Nitbani, Febri Odel [1 ,3 ]
Jumina [1 ]
Siswanta, Dwi [1 ]
Sholikhah, Eti Nurwening [2 ]
Fitriastuti, Dhina [4 ]
机构
[1] Univ Gadjah Mada, Fac Math & Nat Sci, Dept Chem, Yogyakarta, Indonesia
[2] Univ Gadjah Mada Yogyakarta, Fac Med, Dept Pharmacol & Therapy, Yogyakarta, Indonesia
[3] Univ Nusa Cendana, Fac Sci & Engn, Dept Chem, Kupang, Indonesia
[4] Univ Islam Indonesia, Fac Math & Nat Sci, Dept Chem, Yogyakarta, Indonesia
关键词
Coconut oil; Ethanolysis; Monoacylglycerol; Monolaurin; Antibacterial;
D O I
10.13005/ojc/320632
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Ethanolysis reaction triglyceride from coconut oil using enzyme from lipozyme TL IM has produced a mixture of 2-mono acyl glycerol. Product 2-mono acyl glycerol with a yield of 35% has been achieved in the ratio by weight of triglyceride from coconut oil to dry ethanol is 1: 4, temperature of 35 degrees C, the number of lipozyme TL IM 5% (w/w) of the total weight of the reactants and reaction time 12 hours. The 2-monolaurin compound with a purity of 100% and a yield of 30, 1 % successfully separated from 2-mono acyl glycerol. The 2-monolaurin compound inhibited the growth of Staphylococcus aureus and Bacillus cereus at a concentration of 2500 ppm each with a diameter of inhibitory zone 13.75 and 10.44 mm. Product mixture 2-mono acylglycerol inhibited the growth of Staphylococcus aureus and Bacillus cereus respectively at concentrations of 100 and 1000 ppm with a diameter of inhibitory zone 10.32 and 10.83 mm.
引用
收藏
页码:3113 / 3120
页数:8
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