Alteration by EGTA of the human red cell Ca2+-ATPase

被引：3
|
作者：
Romero, PJ
Salas, V
机构：
[1] Instituto de Biología Experimental, Facultad de Ciencias, Universidad Central de Venezuela, Caracas, 1041-A
来源：
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES | 1995年 / 1240卷 / 02期
关键词：
ATPase; Ca2+-; modulation by EGTA; activation by EGTA; EGTA; erythrocyte; (human);
D O I：
10.1016/0005-2736(95)00206-5
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The effect of EGTA on Ca2+-ATPase activity was studied in fragmented membranes and solubilized preparations from human red cells. A dual action was found. At low concentrations (0.1-1 mM), EGTA increased Ca2+ affinity without affecting V-max. By contrast, at high concentrations (5-10 mM), EGTA was inhibitory. Both effects were partially reversible.
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页码：115 / 117
页数：3
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