INHIBITION OF RAPID POTASSIUM FLUX DURING CEREBRAL-ISCHEMIA INVIVO WITH AN EXCITATORY AMINO-ACID ANTAGONIST

被引：15

作者：

KATAYAMA, Y ^{[1
]}

TAMURA, T ^{[1
]}

BECKER, DP ^{[1
]}

TSUBOKAWA, T ^{[1
]}

机构：

[1] UNIV CALIF LOS ANGELES, SCH MED, DIV NEUROSURG, LOS ANGELES, CA 90024 USA

来源：

BRAIN RESEARCH | 1991年 / 568卷 / 1-2期

关键词：

CEREBRAL ISCHEMIA; EXCITATORY AMINO ACID; KYNURENIC ACID; POTASSIUM ION; MICRODIALYSIS; SPREADING DEPRESSION;

D O I：

10.1016/0006-8993(91)91412-T

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Previous studies have demonstrated that microdialysis is capable of detecting an abrupt and massive increase in extracellular K+ concentration ([K+]e) and a concomitant increase in extracellular concentration of excitatory amino acids (EAAs) during cerebral ischemia in the rat hippocampus in vivo. Following in situ administration of kynurenic acid (KYN), a broad-spectrum antagonist of EAAs, through the dialysis probe (5-10 mM), a delay in reaching the maximum level of increased [K+]e was observed in a dose-dependent manner. The initial component of the rapid increase in [K+]e appears to be mediated by EAAs released from nerve terminals.

引用

页码：294 / 298

页数：5

共 33 条

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