INHIBITION OF RAPID POTASSIUM FLUX DURING CEREBRAL-ISCHEMIA INVIVO WITH AN EXCITATORY AMINO-ACID ANTAGONIST

被引：15
|
作者：
KATAYAMA, Y [1 ]
TAMURA, T [1 ]
BECKER, DP [1 ]
TSUBOKAWA, T [1 ]
机构：
[1] UNIV CALIF LOS ANGELES, SCH MED, DIV NEUROSURG, LOS ANGELES, CA 90024 USA
来源：
BRAIN RESEARCH | 1991年 / 568卷 / 1-2期
关键词：
CEREBRAL ISCHEMIA; EXCITATORY AMINO ACID; KYNURENIC ACID; POTASSIUM ION; MICRODIALYSIS; SPREADING DEPRESSION;
D O I：
10.1016/0006-8993(91)91412-T
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Previous studies have demonstrated that microdialysis is capable of detecting an abrupt and massive increase in extracellular K+ concentration ([K+]e) and a concomitant increase in extracellular concentration of excitatory amino acids (EAAs) during cerebral ischemia in the rat hippocampus in vivo. Following in situ administration of kynurenic acid (KYN), a broad-spectrum antagonist of EAAs, through the dialysis probe (5-10 mM), a delay in reaching the maximum level of increased [K+]e was observed in a dose-dependent manner. The initial component of the rapid increase in [K+]e appears to be mediated by EAAs released from nerve terminals.
引用
收藏
页码：294 / 298
页数：5
相关论文
共 50 条
  • [1] INHIBITION OF THE EARLY PHASE OF FREE FATTY-ACID LIBERATION DURING CEREBRAL-ISCHEMIA BY EXCITATORY AMINO-ACID ANTAGONIST ADMINISTERED BY MICRODIALYSIS
    KATAYAMA, Y
    KAWAMATA, T
    MAEDA, T
    ISHIKAWA, K
    TSUBOKAWA, T
    BRAIN RESEARCH, 1994, 635 (1-2) : 331 - 334
  • [2] EXCITATORY AMINO-ACID RECEPTORS AND THEIR ROLE IN EPILEPSY AND CEREBRAL-ISCHEMIA
    MELDRUM, BS
    DIVERSITY OF INTERACTING RECEPTORS, 1995, 757 : 492 - 505
  • [3] EXCITATORY AMINO-ACID ANTAGONIST ADMINISTERED VIA MICRODIALYSIS ATTENUATES LACTATE ACCUMULATION DURING CEREBRAL-ISCHEMIA AND SUBSEQUENT HIPPOCAMPAL DAMAGE
    KATAYAMA, Y
    KAWAMATA, T
    KANO, T
    TSUBOKAWA, T
    BRAIN RESEARCH, 1992, 584 (1-2) : 329 - 333
  • [4] CEREBRAL-ISCHEMIA AND EXCITATORY AMINO-ACID TRANSMITTER-INDUCED NEURODEGENERATION - EFFECTS OF MONOSIALOGANGLIOSIDE TREATMENT
    SEREN, MS
    LAZZARO, A
    RUBINI, R
    ZANONI, R
    SKAPER, SD
    LEON, A
    PHARMACOLOGY OF CEREBRAL ISCHEMIA 1988, 1989, : 285 - 288
  • [5] SODIUM-CHANNEL BLOCKADE INHIBITS EXCITATORY AMINO-ACID RELEASE IN FOCAL CEREBRAL-ISCHEMIA
    GRAHAM, SH
    CHEN, J
    LEACH, M
    SIMON, RP
    NEUROLOGY, 1991, 41 (07) : 1161 - 1161
  • [6] DYNAMIC CHANGES OF EXCITATORY AMINO-ACID RECEPTORS IN THE RAT HIPPOCAMPUS FOLLOWING TRANSIENT CEREBRAL-ISCHEMIA
    WESTERBERG, E
    MONAGHAN, DT
    KALIMO, H
    COTMAN, CW
    WIELOCH, TW
    JOURNAL OF NEUROSCIENCE, 1989, 9 (03): : 798 - 805
  • [7] CALCIUM-DEPENDENT GLUTAMATE RELEASE CONCOMITANT WITH MASSIVE POTASSIUM FLUX DURING CEREBRAL-ISCHEMIA INVIVO
    KATAYAMA, Y
    KAWAMATA, T
    TAMURA, T
    HOVDA, DA
    BECKER, DP
    TSUBOKAWA, T
    BRAIN RESEARCH, 1991, 558 (01) : 136 - 140
  • [8] CHANGES IN EXTRACELLULAR AMINO-ACID NEUROTRANSMITTERS PRODUCED BY FOCAL CEREBRAL-ISCHEMIA
    GRAHAM, SH
    SHIRAISHI, K
    PANTER, SS
    SIMON, RP
    FADEN, AI
    NEUROSCIENCE LETTERS, 1990, 110 (1-2) : 124 - 130
  • [9] EFFECT OF PENTOXIFYLLINE ON CEREBRAL-ISCHEMIA AND AMINO-ACID INCORPORATION INTO GERBIL BRAIN
    COHEN, MM
    HARRISON, W
    GRAY, R
    BECKER, R
    ANNALS OF NEUROLOGY, 1979, 6 (02) : 162 - 162
  • [10] CEREBRAL SYNTHESIS AND RELEASE OF KYNURENIC ACID - AN ENDOGENOUS ANTAGONIST OF EXCITATORY AMINO-ACID RECEPTORS
    SWARTZ, KJ
    DURING, MJ
    FREESE, A
    BEAL, MF
    JOURNAL OF NEUROSCIENCE, 1990, 10 (09): : 2965 - 2973
12345