APPLICATION OF THE SUZUKI BIPHENYL SYNTHESIS TO THE NATURAL-PRODUCTS BIPHENOMYCIN AND VANCOMYCIN

被引：56

作者：

BROWN, AG ^{[1
]}

CRIMMIN, MJ ^{[1
]}

EDWARDS, PD ^{[1
]}

机构：

[1] SMITHKLINE BEECHAM PHARMACEUT,DIV RES,BROCKHAM PK,BETCHWORTH RH3 7AJ,SURREY,ENGLAND

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1992年 / 01期

关键词：

D O I：

10.1039/p19920000123

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of the unsymmetrical biphenyls 10 and 25 has been carried out by the palladium(0) catalysed coupling of the aryl boronic acid derivatives 5 and 20 with the aryl bromides 9 and 23 derived from (R)-4-hydroxyphenylglycine and (S)-tyrosine. In the former case unsuccessful attempts were made to bring about cyclization to compound 4 which is an analogue of the biphenyl ring system found in vancomycin. In the latter case, a variety of cyclization methods were used to give the cyclic products 34 and 35 which are analogues of the biphenomycin antibiotics.

引用

页码：123 / 130

页数：8

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