RESTING [CA-2+]I AND [CA-2+]I TRANSIENTS ARE SIMILAR IN FIBROBLASTS FROM NORMAL AND ALZHEIMERS DONORS

被引：29
|
作者：
BORDEN, LA [1 ]
MAXFIELD, FR [1 ]
GOLDMAN, JE [1 ]
SHELANSKI, ML [1 ]
机构：
[1] COLUMBIA UNIV,COLL PHYSICIANS & SURGEONS,DEPT PATHOL,630 W 168TH ST,NEW YORK,NY 11203
来源：
NEUROBIOLOGY OF AGING | 1992年 / 13卷 / 01期
关键词：
ALZHEIMERS DISEASE; FIBROBLASTS; CALCIUM; BRADYKININ;
D O I：
10.1016/0197-4580(92)90005-I
中图分类号：
R592 [老年病学]; C [社会科学总论];
学科分类号：
03 ; 0303 ; 100203 ;
摘要：
Previous studies have reported that resting concentrations of intracellular calcium ion were markedly reduced in cultured dermal fibroblasts from Alzheimer's disease patients and that the ability of these cells to respond ro serum stimulation was also decreased as compared to both young and age-matched control cells. In this study we have carefully reexamined these parameters in several of the same lines of fibroblasts and fail to find major differences in resting cytosolic calcium [Ca2+]i, in the response of [Ca2+]i to serum stimulation or in cell spreading in the AD cells as compared to young controls. The present findings suggest that cytoplasmic ionic calcium levels are neither pathognomonic for Alzheimer's cells nor of diagnostic value.
引用
收藏
页码：33 / 38
页数：6
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